Analysis of intracranial pressure pulse waveform and brain capillary morphology in type 2 diabetes mellitus rats

Brain Research
Hidetaka OnoderaTakuo Hashimoto

Abstract

Diabetes mellitus in neurosurgical patients is known to be a disease with high risks and severe outcomes. However, the mechanism by which diabetes mellitus induces dysfunction of brain tissue is not well known. The hypothesis of this study was that the damage to brain microvasculature in diabetes mellitus results in impaired compliance of the brain. Pathological changes associated with type II diabetes were investigated using a rat model. Pathophysiological changes in diabetic brain tissue were also investigated to confirm cerebral compliance by analyzing intracranial pressure waveforms. Pathologic findings revealed thickening of the basement membrane and fibrous collagen infiltration into the inner basement membrane of the brain microvasculature in diabetes mellitus. Analysis of intracranial pressure waveforms revealed that the P2 portion increased in diabetic rats compared to the control and was increased further with the increase in intracranial pressure. Analysis of the differential pressure curve, with respect to time, demonstrated that intracranial elasticity showed a concomitant increase. Pathologic findings and intracranial pressure waveforms were consistent with changes in brain microvasculature in diabetes mellitus. T...Continue Reading

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Citations

Dec 23, 2014·Future Neurology·Paco S Herson, Richard J Traystman
Jul 29, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Maj S ThomsenTorben Moos
Oct 19, 2017·Journal of Neuropathology and Experimental Neurology·Vigdis Andersen EidsvaagPer K Eide
May 20, 2017·Brain and Behavior·Radek FričPer Kristian Eide

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