Analysis of intrahepatic HBV-specific cytotoxic T-cells during and after acute HBV infection in humans

Journal of Hepatology
Dave SprengersH L A Janssen

Abstract

Characteristics of the intrahepatic virus-specific T-cell response in patients with acute hepatitis B virus (HBV) infection have not been studied due to the risk of complications associated with standard liver biopsies. In this study we aimed to characterize the virus-specific CD8 + T-cell response in the liver of patients with acute HBV infection using fine-needle aspiration-biopsy (FNAB). In HLA-A2 positive patients with acute HBV infection a FNAB was performed at first presentation, at the time of HBsAg-seroconversion and 3 months after HBsAg-seroconversion. HLA-A2 tetramers were used to identify HBV-specific CD8 + T-cells in FNAB-cytology and peripheral blood (PB). At first presentation there was a correlation between the frequency of intrahepatic CD8 + T-cells and the degree of liver damage. At all time points there was sequestering of HBV-specific CD8 + T-cells in the liver, and the percentage of intrahepatic HLA-DR expressing HBV-specific CD8 + T-cells was higher than in PB. Three months after HBsAg-seroconversion the frequency of intrahepatic HBV-specific CD8 + T-cells remained high. HBV-specific CD8 + T-cells are compartmentalized in the liver during acute HBV infection. Their presence in the liver may suggest a role i...Continue Reading

References

Nov 1, 1993·The Journal of Experimental Medicine·K AndoF V Chisari
Sep 1, 1996·The Journal of Clinical Investigation·A PennaC Ferrari
Oct 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G J WebsterA Bertoletti
Feb 15, 2001·The New England Journal of Medicine·A A BravoS Chopra
Dec 7, 2002·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Hubert G M Niesters
May 27, 2004·European Journal of Immunology·Scott M WardPaul Klenerman
Sep 1, 2004·Journal of Hepatology·Dave SprengersHarry L A Janssen

❮ Previous
Next ❯

Citations

Feb 23, 2011·The Journal of Clinical Investigation·Lucienne Chatenoud, Jean-François Bach
Aug 17, 2014·Microbial Pathogenesis·Xuefen LiYu Chen
Aug 1, 2014·PLoS Computational Biology·Stanca M CiupeAlan S Perelson
Jul 20, 2010·Clinics in Liver Disease·Kyong-Mi Chang
Nov 6, 2007·Clinics in Liver Disease·John M Vierling
Oct 10, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J Judy ChangSharon R Lewin
Aug 13, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Seung Ku LeeKyubum Kwack
Jun 19, 2013·Immunological Reviews·Christina C ChangSharon R Lewin
Apr 7, 2010·Journal of Viral Hepatitis·M John von FreyendU Protzer
Oct 1, 2009·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Zhengsheng ZouFu-Sheng Wang
Mar 7, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S T MartinS Gabardi
Jun 24, 2006·Journal of Hepatology·Gabriele Missale
Apr 17, 2015·Immunological Reviews·Amina A Negash, Michael Gale
Nov 30, 2006·Immunology and Cell Biology·J Judy Chang, Sharon R Lewin
May 7, 2021·Frontiers in Immunology·Yara O AghabiZania Stamataki

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.