Analysis of iris surface features in populations of diverse ancestry

Royal Society Open Science
Melissa EdwardsEsteban J Parra

Abstract

There are many textural elements that can be found in the human eye, including Fuchs' crypts, Wolfflin nodules, pigment spots, contraction furrows and conjunctival melanosis. Although iris surface features have been well-studied in populations of European ancestry, the worldwide distribution of these traits is poorly understood. In this paper, we develop a new method of characterizing iris features from photographs of the iris. We then apply this method to a diverse sample of East Asian, European and South Asian ancestry. All five iris features showed significant differences in frequency between the three populations, indicating that iris features are largely population dependent. Although none of the features were correlated with each other in the East and South Asian groups, Fuchs' crypts were significantly correlated with contraction furrows and pigment spots and contraction furrows were significantly associated with pigment spots in the European group. The genetic marker SEMA3A rs10235789 was significantly associated with Fuchs' crypt grade in the European, East Asian and South Asian samples and a borderline association between TRAF3IP1 rs3739070 and contraction furrow grade was found in the European sample. The study of ir...Continue Reading

References

Jan 1, 1965·Acta Ophthalmologica·A W ErikssonH Forsius
Oct 1, 1981·Developmental Medicine and Child Neurology·R D Brooke Williams
Oct 5, 1994·Journal of the National Cancer Institute·E P HornM A Tucker
Apr 1, 1996·Archives of Ophthalmology·C L WilkersonD M Albert
Apr 1, 1996·Archives of Ophthalmology·P D ImeschI H Wallow
Nov 5, 1999·Nature Medicine
Dec 25, 2003·The British Journal of Ophthalmology·J W HarbourM Gordon
Jan 1, 1951·Acta Ophthalmologica·E SKELLER, J ØSTER
Jan 1, 1943·Transactions of the American Ophthalmological Society·A B Reese
Feb 7, 2008·American Journal of Human Genetics·Richard A SturmGrant W Montgomery
Jan 9, 2009·Clinical & Experimental Ophthalmology·Bertil Damato, Sarah E Coupland
Jul 22, 2009·The Journal of Physical Chemistry. B·Dana N PelesJohn D Simon
Jul 22, 2009·Pigment Cell & Melanoma Research·Richard A Sturm, Mats Larsson
Dec 24, 2010·Clinical & Experimental Ophthalmology·David A MackeyAlex W Hewitt
Jun 2, 2011·American Journal of Human Biology : the Official Journal of the Human Biology Council·Ellen E QuillenMark D Shriver
Jan 11, 2014·Ophthalmology·Elizabeth SidharthaChing-Yu Cheng
Oct 25, 2014·Investigative Ophthalmology & Visual Science·Elizabeth SidharthaChing-Yu Cheng
Nov 2, 2014·The British Journal of Ophthalmology·Christoph SchwabErika Richtig

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Citations

Feb 20, 2019·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·K R KochL M Heindl
Sep 30, 2019·The British Journal of Ophthalmology·Shweta BirlaViney Gupta
Aug 16, 2018·Healthcare Informatics Research·HyeJung JangYungKyung Park
Dec 24, 2018·Scientific Reports·Lavinia Postolache, Cameron F Parsa
Oct 8, 2020·International Journal of Dermatology·Elisabeth Gómez-MoyanoLeandro Martínez Pilar
Mar 21, 2020·The British Journal of Ophthalmology·Zhi Da SohChing-Yu Cheng
Jul 12, 2017·Psychiatry Research·Dániel Trixler, Tamás Tényi
Mar 17, 2017··Raul MalutanSeptimiu Crisan
Apr 16, 2020··V. K. Kutty MaluNazrin Jariya

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