Analysis of key candidate genes and pathways of endometriosis pathophysiology by a genomics-bioinformatics approach

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Zhimin ZhangXiaoguang Yao

Abstract

Endometriosis is a common disease in women, but the signaling pathways and driven genes involved remain unclear. This study integrated four datasets to elucidate potential key candidate genes and pathways in endometriosis. Four expression profile datasets including 29 endometriosis lesions and 37 normal tissues were integrated and analyzed. Differentially expressed genes (DEGs) were sorted, and the gene ontology, pathway enrichment, and protein-protein interaction network of candidate genes were then analyzed. A total of 94 shared DEGs were identified from the four datasets. The DEGs were clustered based on functions and signaling pathways through the analysis of significant enrichment. Among the DEG protein-protein interaction network complex, 87 nodes/DEGs were identified. Furthermore, 18 central node genes were identified, and most of the corresponding genes were involved in the angiotensin system, smooth muscle contraction, cell junction organization, and lipoxin pathways. Through integrated bioinformatic analysis, we identified candidate genes and pathways in endometriosis, which could improve our understanding of endometriosis.

References

Apr 13, 2002·Annals of the New York Academy of Sciences·Daniel W Cramer, Stacey A Missmer
Aug 6, 2004·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Luigi CobellisFelice Petraglia
Aug 9, 2008·The American Journal of Pathology·M Louise HullD Stephen Charnock-Jones
Dec 6, 2008·Human Reproduction·Juan A Garcia-Velasco, Edgardo Somigliana
Dec 9, 2008·Biochimica Et Biophysica Acta·Tracey A Martin, Wen G Jiang
Feb 10, 2009·Fertility and Sterility·Juliana MeolaLúcia Martelli
Dec 1, 2010·Pharmacology & Therapeutics·Andrew MacKenzie
Nov 17, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Yao-Yuan HsiehFuu-Jen Tsai
Jan 11, 2012·American Journal of Reproductive Immunology : AJRI·Zhangye XuYingping Huang
Dec 4, 2012·Nucleic Acids Research·Andrea FranceschiniLars J Jensen
Mar 6, 2013·Journal of Cellular Physiology·Stefania CrispiPietro G Signorile
Oct 11, 2014·The Journal of Obstetrics and Gynaecology Research·Bulent CakmakOytun Erbaş
Sep 1, 2017·American Journal of Reproductive Immunology : AJRI·Ruiying DiaoYong-Gang Duan
Dec 13, 2017·The Journal of Steroid Biochemistry and Molecular Biology·Azar PazhohanAligholi Sobhani

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.