Analysis of key cell-cycle checkpoint proteins in colorectal tumours

The Journal of Pathology
Judith A McKayGraeme I Murray

Abstract

Aberrations in the components of cell-cycle checkpoints are a common feature of many tumours and several have been shown to have prognostic significance in colorectal cancer. In this study, seven components of cell-cycle control [cyclin D1, retinoblastoma (pRb), p21, p27, p16, p53, and proliferating cell nuclear antigen (PCNA)] were examined in a large series of well-characterized colorectal adenocarcinomas using immunohistochemistry to ascertain co-regulation and influence on survival. The majority (92%) of the tumours had abnormal staining of > or =2 cell-cycle control factors. Expression of cyclin D1 protein was correlated with both p21 (p<0.001) and p27 (p=0.033), suggesting co-regulation of these proteins in colorectal tumours. Only cyclin D1 (p=0.048) and p53 (p=0.025) were directly associated with PCNA levels, suggesting a more important role in the proliferative capacity of tumour cells. Significant associations between cell cycle-related proteins and clinicopathological data were observed: cyclin D1 and p53 proteins were correlated with patient age (p=0.042 and p<0.001, respectively) and p53 (p=0.01) and p21 (p=0.024) proteins were associated with tumour site. Expression of cyclin D1 protein was the only protein examin...Continue Reading

References

Sep 1, 1992·British Journal of Cancer·T StarzynskaP L Stern
Feb 1, 1995·Clinical Science·R A Boulton, H J Hodgson
Jun 19, 1993·International Journal of Cancer. Journal International Du Cancer·D M ParkinJ Ferlay
Feb 20, 1996·International Journal of Cancer. Journal International Du Cancer·X F SunB Nordenskjöld
Apr 22, 1996·International Journal of Cancer. Journal International Du Cancer·C GillettD Barnes
Nov 1, 1996·Proceedings of the Society for Experimental Biology and Medicine·A L GartelA L Tyner
Dec 6, 1996·Science·C J Sherr
Sep 1, 1996·The Journal of Pathology·P A HallD P Lane
Dec 20, 1996·International Journal of Cancer. Journal International Du Cancer·A ParadisoM De Lena
Feb 1, 1997·Nature Medicine·P S Steeg, J S Abrams
Mar 6, 1997·Biochemical and Biophysical Research Communications·S SiavoshianJ P Galmiche
Nov 18, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W R Sellers, W G Kaelin
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·S A EzhevskyS F Dowdy
Sep 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D G Kirsch, M B Kastan
Jan 15, 1999·British Journal of Cancer·H L McLeod, G I Murray
Jan 20, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R PalmqvistG Landberg
Feb 23, 1999·The American Journal of Pathology·R V LloydB W Scheithauer
May 18, 1999·Journal of the National Cancer Institute·S G SwisherM K Waugh
Jun 17, 1999·International Journal of Cancer. Journal International Du Cancer·K HandaT Takahashi
Aug 17, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M IlyasW F Bodmer
Mar 17, 2000·International Journal of Cancer. Journal International Du Cancer·T K ZirbesH P Dienes
Jun 1, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·Y H ShimJ Y Ro
Jun 22, 2000·International Journal of Cancer. Journal International Du Cancer·J YaoP Y Cheah
Aug 30, 2000·International Journal of Cancer. Journal International Du Cancer·J A McKayH L McLeod

❮ Previous
Next ❯

Citations

Jul 26, 2005·International Journal of Colorectal Disease·Tin Oo KhorHeng Fong Seow
Jan 10, 2006·Diseases of the Colon and Rectum·Marja HilskaPeter J Roberts
Aug 29, 2003·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S E TheocharisA S Koutselinis
Nov 21, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J A McKayH L McLeod
Jan 15, 2009·Nature Reviews. Cancer·Erik S Knudsen, Karen E Knudsen
Feb 22, 2005·Applied Immunohistochemistry & Molecular Morphology : AIMM·Banu LebeAli Küpelioğlu
Nov 19, 2011·Applied Immunohistochemistry & Molecular Morphology : AIMM·Imen Miladi-AbdennadherRaja Mokdad-Gargouri
Jun 11, 2009·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·R SarkarD G Jayne
Jun 10, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Shuji OginoCharles S Fuchs
Jun 25, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shuji OginoCharles S Fuchs
Sep 24, 2004·BMC Gastroenterology·Abeer A BahnassyMostafa El-Serafi
Jan 24, 2006·World Journal of Surgical Oncology·Gregory KouraklisCrysoula Sioka
Feb 28, 2008·Annals of Surgical Oncology·Sarli LeopoldoBordi Cesare
Oct 8, 2015·Molecular Nutrition & Food Research·Xian WuHang Xiao
Nov 25, 2006·Surgical Oncology·Leopoldo SarliCesare Bordi
Dec 31, 2005·Annals of the New York Academy of Sciences·Ching Ching LeowWei-Qiang Gao
Jan 28, 2014·Journal of Surgical Oncology·Lutfiye DemirMustafa Oktay Tarhan
Jun 19, 2004·Pathology·Rooshdiya KarimSoon Lee
Oct 17, 2008·Journal of Experimental & Clinical Cancer Research : CR·Zheng LiuKejia Ding
Jul 16, 2008·Biochimica Et Biophysica Acta·Ioannis A Voutsadakis
Aug 15, 2003·World Journal of Gastroenterology : WJG·Hong-Bo WeiJi-Fu Wang
Feb 28, 2019·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Yuewen QiBingqing Li
May 13, 2004·British Journal of Cancer·L C LawrieG I Murray
Feb 5, 2004·World Journal of Gastroenterology : WJG·Wen JinDai-Xing Yang
Oct 31, 2006·World Journal of Gastroenterology : WJG·Basak DoganavsargilMuge Tuncyurek

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Related Papers

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
R PalmqvistG Landberg
Virchows Archiv : an International Journal of Pathology
I R K Bukholm, J M Nesland
© 2022 Meta ULC. All rights reserved