PMID: 8959680Nov 1, 1996Paper

Analysis of L-myc and GSTM1 genotypes in Chinese non-small cell lung carcinoma patients

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
H GeM L Lung

Abstract

The genotypes of L-myc and GSTM1 genes were studied in normal lung tissues of 98 non-small cell lung carcinoma (NSCLC) patients from Hong Kong using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) techniques. Results showed a statistical difference in L-myc genotypes between Chinese and African Americans (P = 0.02). A significant deficit in heterozygotes resulting in the departure from Hardy-Weinberg equilibrium in lung cancer female patients was detected (0.01 < P < 0.02). There were significant differences in survival times in patients having L-L and S-S genotypes, with shorter survival times in the patients with L-L genotypes (0.01 < P < 0.05). Data on age, size of tumor, histological types, and lymph node metastasis showed no significant association with L-myc genotype. The survival time in the GSTM1-negative (null gene) group was significantly different from the GSTM1 positive group between 16 and 24 months after operation (0.01 < P < 0.05). There was no significant difference in the distribution of GSTM1 genotypes between Chinese and Caucasian Americans.

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Citations

Mar 10, 2000·International Journal of Cancer. Journal International Du Cancer·A V TogoE N Imyanitov
Aug 9, 2001·International Journal of Cancer. Journal International Du Cancer·M SpinolaT A Dragani
Feb 15, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Ping YangWanguo Liu
Apr 17, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Chuen-Ming ShihYi-Ching Wang
Aug 24, 2010·Pharmacogenetics and Genomics·Scott M LangevinUNKNOWN Genetic Susceptibility to Environmental Carcinogens group (GSEC)
Sep 8, 2011·International Journal of Medical Sciences·Antonis ValachisEvangelos G Papanikolau
Jan 6, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Anne M HorganGeoffrey Liu
Apr 13, 2004·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·M SpinolaT A Dragani
Dec 6, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Monica SpinolaTommaso A Dragani
Oct 9, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Xin-Ping ChenSheng-Miao Fu
Apr 1, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yan ZhaoWeiquan Lu
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May 9, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kyoung-Mu LeeEmanuela Taioli

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