Analysis of lipid metabolism and its impact on the risk of ischemic heart disease in patients with definite familial hypercholesterolemia

Atherosclerosis. Supplements
Viktoria KornevaUlrich Julius

Abstract

to analyze the relationship between lipid disturbance, including lipoprotein(a) (Lp(a)) levels, and development of ischemic heart disease (IHD) in patients with familial hypercholesterolemia (FH). 81 patients (middle age was 39.1 ± 0.4 years, 33 males, 48 females) with a definite FH were examined. The concentration of Lp(a) was determined by immunoturbidimetric method. Lipid profiles were estimated by enzymatic colorimetric method. Lp(a) levels were elevated in 41.9% of FH patients. In FH patients with elevated Lp(a) (>0.3 g/l) IHD occurred 1.7 times more often, myocardial infarction - 2.76 times. The risk of IHD in FH patients was increased in individuals with Lp(a) 1.2 g/l and above. Lp(a) elevation plays an additional role in IHD appearance in FH.

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