Analysis of lipids with desorption atmospheric pressure photoionization-mass spectrometry (DAPPI-MS) and desorption electrospray ionization-mass spectrometry (DESI-MS)

Journal of Mass Spectrometry : JMS
Niina M SuniRisto Kostiainen

Abstract

In this article, the effect of spray solvent on the analysis of selected lipids including fatty acids, fat-soluble vitamins, triacylglycerols, steroids, phospholipids, and sphingolipids has been studied by two different ambient mass spectrometry (MS) methods, desorption electrospray ionization-MS (DESI-MS) and desorption atmospheric pressure photoionization-MS (DAPPI-MS). The ionization of the lipids with DESI and DAPPI was strongly dependent on the spray solvent. In most cases, the lipids were detected as protonated or deprotonated molecules; however, other ions were also formed, such as adduct ions (in DESI), [M-H](+) ions (in DESI and DAPPI), radical ions (in DAPPI), and abundant oxidation products (in DESI and DAPPI). DAPPI provided efficient desorption and ionization for neutral and less polar as well as for ionic lipids but caused extensive fragmentation for larger and more labile compounds because of a thermal desorption process. DESI was more suitable for the analysis of the large and labile lipids, but the ionization efficiency for less polar lipids was poor. Both methods were successfully applied to the direct analysis of lipids from pharmaceutical and food products. Although DESI and DAPPI provide efficient analysis ...Continue Reading

References

Oct 20, 1999·Journal of Chromatography. a·W M Niessen
Aug 11, 2000·Journal of the American Society for Mass Spectrometry·T KuuranneR Kostianen
Nov 10, 2000·Journal of the American Society for Mass Spectrometry·S Zhou, K D Cook
May 9, 2002·Mass Spectrometry Reviews·N B Cech, C G Enke
Nov 5, 2003·Journal of Mass Spectrometry : JMS·Elisa BassoPietro Traldi
Feb 10, 2004·Journal of the American Society for Mass Spectrometry·Tiina J KauppilaAndries P Bruins
Oct 6, 2005·European Journal of Mass Spectrometry·Arnaud DelobelOlivier Laprévote
Feb 1, 2006·Chemical Communications : Chem Comm·Hao ChenR Graham Cooks
Oct 13, 2006·Biophysical Chemistry·I Novak, B Kovac
Nov 23, 2006·Rapid Communications in Mass Spectrometry : RCM·Pekka OstmanTapio Kotiaho
Sep 7, 2007·Analytical Chemistry·Markus HaapalaRisto Kostiainen
Sep 27, 2007·Chemical Communications : Chem Comm·Anthony B Costa, R Graham Cooks
Jan 11, 2008·Analytical Chemistry·Sofie P PasilisGary J Van Berkel
Mar 6, 2008·Rapid Communications in Mass Spectrometry : RCM·Tiina J KauppilaRisto Kostiainen
Aug 9, 2008·Science·Demian R IfaR Graham Cooks
Sep 10, 2008·Analytical Chemistry·Laura LuosujärviTiina J Kauppila
Aug 8, 2009·Journal of the American Society for Mass Spectrometry·Hendrik KerstenRob O'Brien
Apr 15, 2010·Rapid Communications in Mass Spectrometry : RCM·Laura LuosujärviTiina J Kauppila
Jun 4, 2010·Analytical and Bioanalytical Chemistry·Rosana M AlbericiMarcos N Eberlin
Jun 15, 2010·Journal of the American Society for Mass Spectrometry·Chang-Ching ChanAthula B Attygalle
Jun 29, 2010·Rapid Communications in Mass Spectrometry : RCM·Stefanie Gerbig, Zoltán Takáts
Nov 12, 2010·Analytical and Bioanalytical Chemistry·Ayanna U JacksonR Graham Cooks
Apr 9, 2011·Forensic Science International : Synergy·Tiina J KauppilaRisto Kostiainen
Apr 19, 2011·Analytical Chemistry·Glenn A HarrisFacundo M Fernández

❮ Previous
Next ❯

Citations

Jan 11, 2013·Chemical Reviews·María Eugenia MongeFacundo M Fernández
Jan 19, 2016·Rapid Communications in Mass Spectrometry : RCM·T J KauppilaR A Ketola
Feb 26, 2015·Analytical Chemistry·Markus HaapalaRisto Kostiainen
Feb 5, 2013·Journal of Mass Spectrometry : JMS·Xiangyu XuJin Ouyang
Jul 22, 2014·Journal of Mass Spectrometry : JMS·Petra HorkáJosef Cvačka
Oct 4, 2014·Rapid Communications in Mass Spectrometry : RCM·Riikka-Marjaana RäsänenTiina J Kauppila
Sep 10, 2015·Rapid Communications in Mass Spectrometry : RCM·Anu VaikkinenTiina J Kauppila
Jul 28, 2015·Rapid Communications in Mass Spectrometry : RCM·Anu VaikkinenTiina J Kauppila
May 16, 2015·Mass Spectrometry Reviews·Tianyang GuoTianwei Tan
May 20, 2015·Mass Spectrometry Reviews·Tiina J KauppilaThorsten Benter
Apr 30, 2013·Progress in Lipid Research·Shane R EllisTodd W Mitchell
Jul 6, 2015·Analytical and Bioanalytical Chemistry·Clara IbáñezAlejandro Cifuentes
Sep 15, 2016·Journal of the American Society for Mass Spectrometry·Kevin BenhamThomas M Orlando
Mar 18, 2017·Critical Reviews in Analytical Chemistry·Hubert BylińskiJacek Namieśnik
Jan 9, 2019·Journal of the American Society for Mass Spectrometry·Kevin BenhamThomas M Orlando
Oct 24, 2019·Analytical and Bioanalytical Chemistry·Riikka-Marjaana RäsänenTiina J Kauppila
May 2, 2018·Journal of the American Society for Mass Spectrometry·Wanpeng AiHuwei Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.