Analysis of lipopolysaccharide antigens of Treponema hyodysenteriae.

Epidemiology and Infection
D J HampsonB Combs

Abstract

Lipopolysaccharide (LPS) extracts obtained from Treponema hyodysenteriae of serogroups A, B, D and E, and from T. innocens were examined by SDS-polyacrylamide gel electrophoresis (SDS-PAGE), silver-staining, and immunoblotting with hyperimmune rabbit sera. All organisms possessed multiple LPS bands, but their position and number differed. Immunoblotting of LPS with grouping sera identified three or four major antigenic LPS components in the 10-42 kDa range in all organisms: these components were largely specific to each type-organism of a serogroup, and presumably represented group antigens. Although some minor cross-reactivity occurred between LPS from organisms in the different groups, this was insufficient to merit changes to the current LPS serogrouping system for T. hyodysenteriae. Besides this LPS 'complex', other higher-molecular-weight material which appeared to be a common component of the treponemes examined was present in low concentrations. Organisms with different serotypes within a serogroup apparently possessed common LPS bands, but also had unique LPS bands which may account for their serotype specificity. One 'untypable' organism lacked group-specific LPS and was thought to be a mutant of a group B organism. Th...Continue Reading

References

Sep 1, 1979·Infection and Immunity·D H Baum, L A Joens
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Dec 1, 1975·Canadian Journal of Microbiology·R R Russell, K G Johnson
Jul 1, 1991·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·M Achacha, S Messier
Feb 1, 1989·Epidemiology and Infection·D J HampsonJ R Buddle
Apr 1, 1989·Veterinary Microbiology·B CombsJ R Buddle
Aug 1, 1985·Journal of Clinical Microbiology·M E Mapother, L A Joens
Nov 1, 1971·The British Veterinary Journal·D J Taylor, T J Alexander
Jan 1, 1982·Analytical Biochemistry·C M Tsai, C E Frasch
Jul 1, 1982·Infection and Immunity·M E NuessenL A Joens
Dec 1, 1982·Infection and Immunity·M E Nuessen, L A Joens

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Citations

Aug 1, 1990·Epidemiology and Infection·D J HampsonJ I Lee
Oct 1, 1992·Epidemiology and Infection·T T Lau, D J Hampson
Jul 1, 1996·World Journal of Microbiology & Biotechnology·S B Sharma, K G Davies
Sep 1, 1996·Progress in Lipid Research·S G Wilkinson
Jan 10, 1998·Clinical and Diagnostic Laboratory Immunology·L N FisherG E Duhamel

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