PMID: 9536820Apr 16, 1998Paper

Analysis of LMP and TAP polymorphisms by polymerase chain reaction-restriction fragment length polymorphism in rheumatoid arthritis

Annals of the Rheumatic Diseases
J VinascoJ Martín

Abstract

The aim of this study was to investigate the relation between the polymorphism of large molecular weight proteasome (LMP) (LMP2-LMP7) and transporter associated with antigen processing (TAP) (TAP1-TAP2) genes and rheumatoid arthritis (RA). Sixty RA patients and 102 ethnically matched unrelated healthy subjects were typed for LMP, TAP, and disease associated HLA-DRB1 alleles by using a new strategy based on polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) with amplification created restriction sites. The polymorphism of LMP (LMP2-LMP7) and TAP (TAP1-TAP2) genes was examined in shared epitope positive and negative RA patients and controls. No significant differences in the LMP or TAP allele frequencies were observed between the total patient and control groups or the patients and controls groups or the patients and controls positive or negative for the shared epitope. The data suggest that the polymorphisms of LMP and TAP genes do not have an important influence in the pathogenesis of RA, although larger studies will be needed to provide more conclusive evidence on the role of these genes in RA. A new, highly reliable strategy for typing LMP alleles is also described.

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Citations

Oct 3, 2003·Ageing Research Reviews·Michele MishtoClaudio Franceschi
Nov 22, 2005·Neurobiology of Aging·Michele MishtoClaudio Franceschi
Nov 2, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Filiz Ozbas-GercekerSibel Oguzkan-Balci
Jun 6, 2002·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·S-L ZhangE Toussirot
Sep 5, 2002·Genes and Immunity·G Vargas-AlarcónJ Granados
Jan 25, 2007·Pediatric Pulmonology·Deniz DoğruMeral Ozgüç
Jan 30, 2004·Genes and Immunity·J L NewtonM A Brown
Oct 18, 2001·Radiation Research·F Pajonk, W H McBride
Apr 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ann M ReedCarole Ober
Dec 18, 2004·Human Immunology·Gilberto Vargas-AlarcónRubén Burgos-Vargas

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