Analysis of LMP1 variants of EBV in Southern Thailand: evidence for strain-associated T-cell tropism and pathogenicity

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Vannarat SaechanTakafumi Ishida

Abstract

The latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) has sequence heterogeneity. Some of the variants are associated with altered tumorigenic activity and show geographically specific localization. In Thailand, the EBV genome is frequently detected in circulating T cells of T-cell diseases. To determine the role of EBV LMP1 variation in the genesis of T-cell diseases, we focused on virus factors and analyzed EBV strains in Thailand. EBV DNA was extracted from 18 healthy individuals and 45 patients with T-cell diseases in Southern Thailand and 30 healthy individuals in Central Thailand. By using PCR-direct sequencing method, nucleotide sequences corresponding to the carboxyl terminus of the LMP1 were determined. Four known strains, B95-8 prototype, China 1, China 2 and Mediterranean (Med) and two novel strains, Southeast Asia 1 (SEA 1) and Southeast Asia 2 (SEA 2) were identified. The prevalence of China 2 strain was significantly different (p=0.006) between Central and Southern Thailand. Higher prevalence (p=0.026) of 30-bp deletion type in the Southern Thais was observed. The LMP1 Med strain was associated with the worse prognosis (p=0.029). Among T-cell diseases patients, CD3(+)-cell oriented infection was recogni...Continue Reading

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Citations

Jan 9, 2008·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Danai TiwawechTakafumi Ishida
Apr 30, 2010·The Journal of General Virology·Vannarat SaechanTakafumi Ishida
Jul 20, 2016·Journal of Medical Virology·Marco NevesHugo Sousa
Dec 31, 2016·The Journal of General Virology·Lu ZhouChun-Kui Shao
Feb 26, 2008·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Y L TangG Y Li
Jan 1, 2012·Pathogens·Stelios Tzellos, Paul J Farrell
Sep 20, 2018·Journal of Medical Virology·Supitcha WanvimonsukNakarin Kitkumthorn

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