Analysis of longitudinal studies with death and drop-out: a case study

Statistics in Medicine
Carole DufouilDavid Clayton

Abstract

The analysis of longitudinal data has recently been an active area of biostatistical research. Two main approaches to analysis have emerged, the first concentrating on modelling evolution of marginal distributions of the main response variable of interest and the other on subject-specific trajectories. In epidemiology the analysis is usually complicated by missing data and by death of study participants. Motivated by a study of cognitive decline in the elderly, this paper argues that these two types of incomplete follow-up may need to be treated differently in the analysis, and proposes an extension to the marginal modelling approach. The problem of informative drop-out is also discussed. The methods are implemented in the 'Stata' statistical package.

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jan 1, 1988·Statistics in Medicine·N M Laird
Dec 1, 1996·Statistical Methods in Medical Research·A Gelman, D B Rubin
Jan 15, 1997·Statistics in Medicine·M Reilly, M Pepe
Jan 15, 1997·Statistics in Medicine·A Rotnitzky, J Robins
Nov 26, 1999·Journal of the American Geriatrics Society·C BrayneF A Huppert

❮ Previous
Next ❯

Citations

Aug 20, 2008·Proceedings of the National Academy of Sciences of the United States of America·Kaare ChristensenJames W Vaupel
Jul 31, 2007·Bioinformatics·Dominik SeelowTom H Lindner
Mar 7, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Lise BathumKaare Christensen
Jan 24, 2012·Journal of Probability and Statistics·Mengling Liu, Wenbin Lu
May 2, 2009·BMC Medical Research Methodology·Nina GunnesOdd O Aalen
Aug 15, 2012·BMC Geriatrics·Fiona MatthewsUNKNOWN Medical Research Council Cognitive Function and Ageing Study
Nov 28, 2008·Arthritis Research & Therapy·Isidoro González-AlvaroUNKNOWN Estudio de la Morbilidad y Expresión Clínica de la Artritis Reumatoide Study Group
Mar 20, 2013·Annals of Family Medicine·John Brodersen, Volkert Dirk Siersma
Feb 19, 2011·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Ian R SmithJames Cameron
Jan 17, 2014·Journal of Epidemiology and Community Health·Charlotte Juul NilssonRikke Lund
Dec 20, 2015·Journal of Alzheimer's Disease : JAD·Kristine HoffmannSteen G Hasselbalch
Feb 18, 2010·Mathematics and Computers in Simulation·Al BartolucciH Randall Griffith
Apr 15, 2015·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Yukari YamadaEva Topinkova
Sep 24, 2015·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Jennifer WeuveUNKNOWN MELODEM Initiative
Nov 28, 2008·Statistics in Medicine·Nina GunnesOdd O Aalen
Jul 5, 2007·Journal of the American Geriatrics Society·Mark ChatfieldUNKNOWN Medical Research Council Cognitive Function and Ageing Study
Mar 12, 2011·Journal of the American Geriatrics Society·Mary W Carter, Frank W Porell
Nov 1, 2012·Journal of the American Geriatrics Society·Maria JosefssonLars Nyberg
Jul 21, 2010·Statistics in Medicine·Kumar B Rajan, Sue E Leurgans
May 5, 2009·Research Quarterly for Exercise and Sport·Christoph Breuer, Pamela Wicker
Aug 2, 2012·Journal of Psychosomatic Research·Daniel FarewellJonathan Bisson
Dec 1, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jakob F RasmussenJ Brodersen
Jun 28, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Nanna Aue SobolNina Beyer
Jan 12, 2011·Statistical Methods in Medical Research·Shaun R Seaman, Ian R White
Sep 8, 2016·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·C CouppéV Siersma
Nov 29, 2016·Journal of the American Geriatrics Society·Jonas W WastessonKaare Christensen
Apr 24, 2012·Statistical Methods in Medical Research·John N S MatthewsLauren R Rodgers
Feb 8, 2014·Scandinavian Journal of Public Health·Tine PoulsenKirsten Avlund
Aug 9, 2017·Statistical Methods in Medical Research·Anaïs RouanetHélène Jacqmin-Gadda
Oct 4, 2017·Physiotherapy Research International : the Journal for Researchers and Clinicians in Physical Therapy·Theresa BielerNina Beyer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.