PMID: 8609128Apr 1, 1996Paper

Analysis of lymph nodes for polyethylene particles in patients who have had a primary joint replacement

The Journal of Bone and Joint Surgery. American Volume
K G SheaK A Samuelson

Abstract

Polarized light microscopy has been used for more than forty years to identify polyethylene particles in histological specimens; however, few investigators have assessed the specificity of this technique. We examined specimens from dissected lymph nodes for the presence of strongly birefringent particles resembling polyethylene. Twenty-seven patients had dissection of lymph nodes after a total joint replacement (Group 1), and a control group of eighteen patients had dissection of lymph nodes before a total joint replacement (Group 2). Specimens from both groups of lymph nodes were examined under plain and polarized light. The presence of strongly birefringent particulate debris was graded from 0 to 4. Twenty-one (78 per cent) of the twenty-seven patients in Group 1 and eight of the eighteen patients in Group 2 had strongly birefringent particles in the lymph nodes. Our results demonstrate that, in the assessment of the systemic dissemination of polyethylene in the lymphoreticular system, polarized light microscopy has important limitations. More refined techniques employing polarized light and other methods of physical and chemical analysis may be necessary to identify polyethylene particles accurately within the lymphoreticula...Continue Reading

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Citations

May 1, 1997·Clinical Orthopaedics and Related Research·R D BloebaumH K Dunn
Feb 3, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·M ScottS Jani
Mar 25, 2014·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Aiqin LiuJoanne L Tipper
Jun 10, 1998·Journal of Biomedical Materials Research·G A LundeenR D Bloebaum
Sep 28, 2000·Journal of Biomedical Materials Research·B M WillieA A Hofmann
Jan 6, 2012·The Journal of Bone and Joint Surgery. American Volume·Matthew J AllenAnton Clifford
Apr 22, 2015·Oral and Maxillofacial Surgery·Aydin GülsesYahya Açil
Mar 16, 2000·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·E Ingham, J Fisher
Aug 10, 2006·Archives of Orthopaedic and Trauma Surgery·Christof BurgerRené H Tolba
Jun 17, 2004·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Bettina M WillieRoy D Bloebaum
Sep 11, 2010·The American Journal of Surgical Pathology·Melissa P PulitzerKlaus Busam
May 1, 1997·Clinical Orthopaedics and Related Research·K G SheaL Zou
Apr 1, 1996·The Journal of Bone and Joint Surgery. American Volume·T W Bauer
Oct 12, 2004·Biomaterials·Eileen Ingham, John Fisher
Aug 15, 2021·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Cornelia Sigrid Lissi MüllerClaudia Pföhler

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