PMID: 8950356Nov 4, 1996Paper

Analysis of lymphocytes from uranium mineworkers in Namibia for chromosomal damage using fluorescence in situ hybridization (FISH)

Mutation Research
R ZaireM A Hultèn

Abstract

Workers in the open pit uranium mine in Namibia appear to suffer from health problems including malignant diseases at a much higher prevalence when compared with the general population. The objective of the present study was to determine whether long-term exposure to low-dose uranium increases the risk of biological radiation damage which could lead to malignant diseases. In order to investigate this risk, we measured the relative frequency of chromosome alterations using Fluorescence in situ hybridization (FISH). A representative cohort of 11 non-smoking miners, were compared to a control group of 9 individuals with no occupational history in mining. We determined a significant increase in chromosome aberrations in the circulating lymphocytes of miners versus the non-smoking controls (p = 0.0000096). Therefore, we concluded that these uranium exposed miners are at an increased risk to acquire genetic damage, which may be associated with an increased risk for malignant transformation.

References

Dec 1, 1990·International Journal of Radiation Oncology, Biology, Physics·J B LittleH Vetrovs
May 1, 1985·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·E J TawnG B Schofield
May 1, 1994·Mutation Research·J R Savage, P Simpson

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Citations

Jul 11, 2002·Mutation Research·G ObeM E Drets
Feb 19, 2003·Journal of Environmental Radioactivity·B UlshJ S Bedford
Jan 1, 2011·Reviews on Environmental Health·Doug Brugge, Virginia Buchner
Dec 31, 2014·Environmental Science and Pollution Research International·Maleke MalekeEsta van Heerden
Jan 6, 2015·The Breast : Official Journal of the European Society of Mastology·Jacques Bernier, Philip Poortmans
Nov 22, 2008·Mutation Research·V Zareena Hamza, Mary N Mohankumar
Oct 14, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Marjorie MonleauMarie Donnadieu-Claraz
Aug 25, 2018·Frontiers in Chemistry·Sepehr ManochehryYingfu Li

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