Analysis of lymphocytes in patients with Plasmodium vivax malaria and its relation to the annexin-A1 and IL-10

Malaria Journal
Quessi I BorgesAmílcar S Damazo

Abstract

Malaria is the most prevalent parasitic disease in the world. In Brazil, the largest number of malaria cases (98%) is within the Legal Amazon region, where Plasmodium vivax is responsible for over 80% of diagnosed cases. The aim of this study was to investigate the annexin-A1 expression in CD4+, CD8+ T cells, regulatory T cells (Treg) and cytokine IL-10 quantification in plasma from patients with malaria caused by P. vivax. The quantification of the cytokine IL-10 of patients infected with P. vivax and healthy controls were evaluated by enzyme-linked immunosorbent assay (ELISA). The determination of the expression of annexin-A1 in lymphocytes from patients and healthy controls was determined by immunofluorescence staining. All results were correlated with the parasitaemia and the number of previous episodes of malaria. The cytokine IL-10 plasma levels showed a significant increase in both patients with low (650.4 ± 59.3 pg/mL) and high (2870 ± 185.3 pg/mL) parasitaemia compared to the control (326.1 ± 40.1 pg/mL). In addition, there was an increase of this cytokine in an episode dependent manner (individuals with no previous episodes of malaria--primoinfected: 363.9 ± 31.1 pg/mL; individuals with prior exposure: 659.9 ± 49.4 pg...Continue Reading

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Citations

Feb 1, 2015·BMC Infectious Diseases·Natália Satchiko Hojo-SouzaLilian Lacerda Bueno
Sep 2, 2016·Malaria Journal·Yury Oliveira ChavesPaulo Afonso Nogueira
Jan 26, 2017·Malaria Journal·Natália Satchiko Hojo-SouzaLilian Lacerda Bueno
Mar 16, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Leandro G OliveiraAna Paula Fernandes
Dec 3, 2020·Revista Da Sociedade Brasileira De Medicina Tropical·Afonso Bezerra RibeiroAmílcar Sabino Damazo
Oct 11, 2021·BMC Infectious Diseases·Stephanni Figueiredo da SilvaAmilcar Sabino Damazo

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Methods Mentioned

BETA
enzyme-linked immunonosorbent assay

Software Mentioned

GraphPad PRISM
Axiovision

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