Analysis of main constituents and mechanisms underlying antidepressant-like effects of Xiaochaihutang in mice

Journal of Ethnopharmacology
Kuo ZhangChun-fu Wu

Abstract

Xiaochaihutang (XCHT), a famous Chinese herbal formula which consists of seven Chinese herbs, has been used clinically in depressive disorders in China. Our previous studies have demonstrated that XCHT improved depressive-like behavior in several animal models of depression. However, therapeutic basis of XCHT on depression are challenging, due to the complex active constituents of XCHT and the unclear pharmacological mechanism of action. To provide further insights into therapeutic basis of XCHT, the core in compatibility of XCHT on antidepressant therapy was assessed by the method of orthogonal array design. The comparative evaluations on antidepressant effects of XCHT and its core in compatibility were executed by tail suspension test (TST), forced swim test (FST), novelty suppressed feeding test (NSFT), reserpine-induced hypothermia and palpebral ptosis. Moreover, the potential mechanism was explored by investigating levels of monoamine neurotransmitters in hypothalamus and striatum and neurogenesis in hippocampus. Chemical profile of active constituents in plasma after oral administration of the core in compatibility of XCHT was revealed by ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The r...Continue Reading

References

Feb 15, 1978·European Journal of Pharmacology·R D PorsoltM Jalfre
Jun 11, 1999·The Journal of Clinical Psychiatry·R M Hirschfeld
Dec 18, 2001·Journal of Ethnopharmacology·C C Sánchez-MateoR M Rabanal
Jun 16, 2004·Behavioural Brain Research·Jun-Xu LiJian-Hui Liang
Aug 12, 2008·Journal of Affective Disorders·Marlene P Freeman
Jul 6, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Cai Song, Hua Wang
Jul 21, 2010·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Zhenyu ZhuYifeng Chai
Mar 16, 2012·The American Journal of Psychiatry·Oliver J RobinsonWayne C Drevets
Jun 21, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mathieu NolletSamuel Leman
Oct 9, 2012·Science·Ronald S Duman, George K Aghajanian
Dec 24, 2013·The Journal of Pharmacy and Pharmacology·Guang Yue SuChun Fu Wu
Jan 21, 2014·Journal of Ethnopharmacology·Guang Yue SuChun Fu Wu

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Citations

Aug 16, 2016·The Journal of Pharmacy and Pharmacology·Jie MaShao Jiang Song
Oct 11, 2019·Cell Proliferation·Yang JinBingjin Li
Jul 26, 2017·Scientific Reports·Zhi-Kun QiuDa-Nian Wei

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