PMID: 42210Oct 1, 1979

Analysis of mammary tumors for cytochemical evidence of endogenous mammary peroxidase

Virchows Archiv. B, Cell Pathology Including Molecular Pathology
J M Strum, P J Becci

Abstract

The purpose of this study was to determine whether or not endogenous mammary peroxidase can serve as a cytochemical marker to distinguish ovarian hormone-dependent from ovarian hormone independent mammary tumors. Spontaneous mammary tumors arising in virgin C3H and GR mice (hormone independent tumors) and hormone-dependent mammary tumors arising during pregnancy in GR mice were examined. None of these tumors contained mammary peroxidase. Mammary tumors induced in Sprague-Dawley rats with methylnitrousourea (MNU) and dimethylbenzanthracene (DMBA) were also examined. These tumors included hormone-dependent and hormone independent ones. Several of the DMBA-induced hormone-dependent tumors contained a few peroxidase-positive cells, but the hormone independent tumors were negative. All of the MNU-induced tumors examined were negative for mammary peroxidase. Twenty human breast tumors (malignant and non-malignant) removed from women at surgery, were also negative for mammary peroxidase. Our results indicate that endogenous mammary peroxidase cannot be used to distinguish hormone-dependent from hormone independent mammary tumors.

References

Nov 1, 1987·Journal of Steroid Biochemistry·M LevinR J Santen
Jan 1, 1981·Acta histochemica·L J van BogaertJ A Quinones
Feb 27, 2003·Breast Cancer Research and Treatment·Geeta UpadhyayMadan M Godbole
Jul 1, 1995·Biological Trace Element Research·B A EskinW R Ghent

Citations

Mar 1, 1970·The Journal of Cell Biology·J M Strum, M J Karnovsky
Jun 1, 1965·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R van Nie, P J Thung
Nov 1, 1960·Stain Technology·K C RICHARDSONE H FINKE
Feb 1, 1961·The Journal of Biophysical and Biochemical Cytology·J H LUFT

Related Concepts

Ovarian Diseases
Ovoperoxidase
9,10-Dimethyl-1,2-benzanthracene
Mammary Gland
Peroxidases
Neoplasms
Ovarian hormone
Rats, Sprague-Dawley
Malignant Paraganglionic Neoplasm
Breast

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