Analysis of Measles-Mumps-Rubella (MMR) Titers of Recovered COVID-19 Patients.

MBio
Jeffrey E GoldJohn W Ashford

Abstract

The measles-mumps-rubella (MMR) vaccine has been theorized to provide protection against coronavirus disease 2019 (COVID-19). Our aim was to determine whether any MMR IgG titers are inversely correlated with severity in recovered COVID-19 patients previously vaccinated with MMR II. We divided 80 subjects into two groups, comparing MMR titers to recent COVID-19 severity levels. The MMR II group consisted of 50 subjects who would primarily have MMR antibodies from the MMR II vaccine, and a comparison group of 30 subjects consisted of those who would primarily have MMR antibodies from sources other than MMR II, including prior measles, mumps, and/or rubella illnesses. There was a significant inverse correlation (rs  = -0.71, P < 0.001) between mumps virus titers (mumps titers) and COVID-19 severity within the MMR II group. There were no significant correlations between mumps titers and severity in the comparison group, between mumps titers and age in the MMR II group, or between severity and measles or rubella titers in either group. Within the MMR II group, mumps titers of 134 to 300 arbitrary units (AU)/ml (n = 8) were found only in those who were functionally immune or asymptomatic; all with mild symptoms had mumps titers below...Continue Reading

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References

Mar 1, 1980·The American Journal of the Medical Sciences·A A GershonS Steinberg
Jan 7, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Arun T KamathDavid F Tough
Apr 19, 2008·The Journal of Infectious Diseases·Irja DavidkinHeikki Peltola
Nov 26, 2008·The American Journal of Medicine·Dennis D TaubDan L Longo
Jan 23, 2009·Journal of Human Genetics·Takashi ShiinaJerzy K Kulski
Nov 7, 2013·Journal of Innate Immunity·Johanneke KleinnijenhuisMihai G Netea
Apr 18, 2015·BMC Public Health·Victoria NankabirwaUNKNOWN PROMISE- EBF Study Group
Apr 23, 2016·Science·Mihai G NeteaRamnik J Xavier
Feb 5, 2019·Journal of the Pediatric Infectious Diseases Society·Mike L T BerendsenPeter Aaby
Mar 7, 2020·Nature Reviews. Immunology·Mihai G NeteaEicke Latz
Mar 18, 2020·Pediatrics·Yuanyuan DongShilu Tong
May 13, 2020·Nature Reviews. Immunology·Luke A J O'Neill, Mihai G Netea
May 22, 2020·The New England Journal of Medicine·Lida Hariri, C Corey Hardin
Jun 2, 2020·Medical Hypotheses·Ramachandran MeenakshisundaramPonniah Thirumalaikolundusubramanian
Jun 6, 2020·Human Vaccines & Immunotherapeutics·Anand AnbarasuPaul Livingstone
Jun 26, 2020·Frontiers in Molecular Biosciences·Karzan R SidiqRimantas Kodzius
Aug 1, 2020·Reviews in Medical Virology·Abdellatif Bouayad

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Citations

Mar 27, 2021·Human Vaccines & Immunotherapeutics·Mina T Kelleni
May 27, 2021·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Van L TranAndrew Nuibe
Jun 30, 2021·Environmental Science and Pollution Research International·Raed Ibrahim AltulayhiMohammad Almohideb
Jul 2, 2021·Frontiers in Public Health·Wen-Ta ChiuJonathan Wu
Apr 19, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Keith C Meyer, Robin K Avery
Aug 21, 2021·Frontiers in Medicine·Brittany A ComunaleQiyi Xie

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