PMID: 6980854Jul 1, 1982Paper

Analysis of membrane lipid composition of mammalian cells during the development of thermotolerance

International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
R L Anderson, R Parker

Abstract

The mechanism by which cells develop thermotolerance is unknown but some previous results suggest that membranes are involved in the process. The lipid composition of membranes from Ehrlich ascites cells grown in tissue culture was analysed at times up to 24 hours after heat treatments at 42 to 44 degrees C known to induce thermotolerance. No changes were observed in the levels of free cholesterol and phospholipids in the cells, nor in the fatty acid composition of the phospholipids. In addition, no changes were observed in the level of cholesterol esters. When cells were fractionated into crude nuclear, mitochondrial and microsomal fractions by differential centrifugation, there was still no heat-induced change in the free cholesterol or phospholipid levels of these fractions. It is concluded that thermotolerance is not mediated through a compositional change in the membranes to a more thermostable form.

References

Oct 26, 1976·Biochimica Et Biophysica Acta·R A Demel, B De Kruyff
Sep 1, 1975·Bacteriological Reviews·J B RattrayD K Kidby
Apr 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A R Cossins, C L Prosser
Jan 1, 1979·Alcoholism, Clinical and Experimental Research·J M LittletonS J Grieve
Mar 8, 1979·Biochimica Et Biophysica Acta·J M Backer, E A Dawidowicz
Jan 1, 1979·The International Journal of Biochemistry·A S Grandison, C Green
Aug 17, 1978·Nature·G C Li, G M Hahn
Nov 16, 1978·Biochimica Et Biophysica Acta·J H ChinD B Goldstein
Jan 14, 1966·Science·L A Ashworth, C Green
Jan 1, 1980·Annals of the New York Academy of Sciences·E W GernerP S Culver
Mar 6, 1981·Biochimica Et Biophysica Acta·R L AndersonG M Hahn

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Citations

Mar 1, 1993·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·M B Yatvin, W A Cramp
Oct 1, 1985·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·R L AndersonS R Cresswell
Nov 1, 1988·International Journal of Radiation Biology·R L AndersonG M Hahn
Aug 1, 1986·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·B Anderstam, M Harms-Ringdahl
Dec 1, 1992·International Journal of Radiation Biology·Z Jóźwiak, W Leyko
May 1, 1986·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·W Leyko, G Bartosz
May 6, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·R L Anderson, S Davis

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