Analysis of menthol in three traditional Chinese medicinal herbs and their compound formulation by GC-MS

Biomedical Chromatography : BMC
Ruimin LinFamei Li

Abstract

A GC-MS method was developed for identification and determination of menthol in three traditional Chinese medicinal herbs and their compound formulation, a granule for treating colds. Volatile oil was simultaneously distilled and extracted into ethyl ether in a unique glass extractor. The separation was performed on an HP-5 MS column. The standard addition method was used for quantitative determination of menthol content in herbal materials and in the granule. A component in the samples was chosen as the internal standard. The contents were calculated with the ratio of peak area percentage. Menthol was identified as the main component in Mentha haplocalyx Briq., and also existed in spikes of Schizonepeta tenuifolia Briq., Folium perilla frutescens (L.) Britt. and granules. The quantitative calibration range was 0.21-10.5 mg/mL. Good precision was demonstrated by an RSD < 4.0%. The mean content of menthol in Mentha haplocalyx Briq., spikes of Schizonepeta tenuifolia Briq., Folium perilla frutescens (L.) Britt. and granules was 121, 0.234, 1.03 and 1.84 mg/kg respectively.

References

Apr 1, 1986·Chemical & Pharmaceutical Bulletin·G HondaM Tabata

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Citations

Nov 24, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Dawei WenHuwei Liu
Mar 14, 2009·Journal of Oleo Science·Nao InoueTeruyoshi Yanagita
Sep 27, 2003·Phytochemical Analysis : PCA
Dec 21, 2007·Pest Management Science·Radhika SamarasekeraKd Patrick Hemalal

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