Analysis of methylphosphonic acid, ethyl methylphosphonic acid and isopropyl methylphosphonic acid at low microgram per liter levels in groundwater

Journal of Chromatography. a
G A SegaW H Griest

Abstract

A method is described for determining methylphosphonic acid, ethyl methylphosphonic acid and isopropyl methylphosphonic acid, which are hydrolysis products of the nerve agents VX (S-2-diisopropylaminoethyl O-ethyl methylphosphonothiolate) and GB (sarin, isopropylmethyl phosphonofluoridate). The analytes are extracted from 50 ml groundwater using a solid-phase extraction column packed with 500 mg of silica with a bonded quaternary amine phase, and are eluted and derivatized with methanolic trimethylphenylammonium hydroxide. Separation and quantitation are achieved using a capillary column gas chromatograph equipped with a flame photometric detector operated in its phosphorus-selective mode. Two independent statistically-unbiased procedures were employed to determine the detection limits, which ranged between 3 and 9 micrograms/l, for the three analytes.

Citations

Sep 9, 2010·Journal of Chromatographic Science·William K FowlerAmber R Wright
Oct 16, 2007·Analytica Chimica Acta·Janelle D S NewmanG J Blanchard
Mar 31, 2015·Chemical Communications : Chem Comm·Rahul R ButalaDavid A Atwood
Mar 12, 2020·Biomolecules·Samir F de A CavalcanteTanos C C França

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