PMID: 2490540Jan 1, 1989

Analysis of miconazole and econazole in pharmaceutical formulations by derivative UV spectroscopy and liquid chromatography (HPLC)

Journal of Pharmaceutical and Biomedical Analysis
V CavriniR Gatti


Methods based on derivative UV spectrophotometry and high-performance liquid chromatography (HPLC) have been developed for the selective determination of miconazole and econazole in pharmaceutical dosage forms. A solid-phase extraction (SPE) procedure using a diol column gave quantitative drug extraction from formulated creams and provided purified sample solutions suitable for assay by the derivative UV spectrophotometric and HPLC methods. The proposed methods gave comparable accurate results, whereas a conventional UV spectrophotometric method was found to be seriously affected by excipients.


Oct 1, 1992·Journal of Pharmaceutical and Biomedical Analysis·A M Di PietraR Gatti
Feb 1, 1992·Journal of Pharmaceutical and Biomedical Analysis·C AlbetJ A Ortiz
Oct 1, 1995·Journal of Pharmaceutical and Biomedical Analysis·D BonazziV Cavrini
Dec 24, 1998·Journal of Pharmaceutical and Biomedical Analysis·D BonazziM Caboni
Mar 7, 2000·Journal of Pharmaceutical and Biomedical Analysis·K WróbelL López-Martínez
Feb 2, 2008·Chemical & Pharmaceutical Bulletin·Bahia Abbas MousaNashwah Gadalla Mohamed
Aug 30, 2003·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Luigi GagliardiDomenica Tonelli
Aug 20, 2010·Journal of Pharmaceutical and Biomedical Analysis·Dadan HermawanHassan Y Aboul-Enein
Nov 26, 2010·Journal of Pharmaceutical and Biomedical Analysis·Prashant Laxman KoleJames C McElnay

Related Concepts

Drug Clearance
Spectrophotometry, Analyte Not Elsewhere Specified in CPT
Spectrophotometry, Ultraviolet
High Pressure Liquid Chromatography Procedure
Paste Substance
Spectrum Analysis

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