PMID: 9435877Jan 1, 1997Paper

Analysis of mitomycin C-induced micronuclei in lymphocytes from malnourished infected children

Environmental and Molecular Mutagenesis
R OrtizM Betancourt

Abstract

The purpose of this study was to determine if peripheral blood lymphocytes from malnourished children with gastrointestinal or respiratory bacterial infection show increased frequencies of Mitomycin C (MMC)-induced micronuclei as compared to well-nourished, infected children. The results indicate that cells from malnourished, infected children had greater chromosome damage. This may indicate that such children would be more susceptible to environmental damage and malignant transformation. Micronucleus frequencies were analyzed in binucleate cells produced by the cytokinesis block method; the overall micronucleus frequency was significantly higher in binucleate cells from malnourished, infected children. The mean micronucleus frequency in MMC-free cultures was 4.3/1000 in malnourished infected children and 1.0/1000 in well-nourished infected children. In MMC-exposed cultures the mean induced micronucleus frequency was 32.6 +/- 6.1 vs. 12.9 +/- 2.3; 68.6 +/- 12.1 vs. 21.0 +/- 5.1, and 88.1 +/- 16.2 vs. 41.7 +/- 5.0 for malnourished and well-nourished children at 20, 40, and 60 ng/ml MMC, respectively. The number of binucleated cells with more than one micronucleus was also higher in malnourished, infected children at all doses te...Continue Reading

References

Dec 1, 1992·International Journal of Radiation Biology·G A SchreiberM Nüsse
Jan 1, 1985·Mutation Research·M Fenech, A A Morley
Feb 1, 1985·Mutation Research·M Fenech, A A Morley
Mar 1, 1994·Mutation Research·D D'Souza, B C Das
Jan 1, 1995·Environmental and Molecular Mutagenesis·R OrtizM Betancourt
Apr 1, 1993·Mutation Research·K WuttkeW U Müller
Jan 1, 1996·Environmental and Molecular Mutagenesis·S Pfuhler, H U Wolf
Sep 1, 1956·The Journal of Tropical Pediatrics·Federico GomezJudith Vazquez

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Citations

Apr 6, 2004·Environmental and Molecular Mutagenesis·Rocío OrtizEdith Cortés
Nov 29, 2011·Mutation Research·Elsa Cervantes-RíosLeonor Rodríguez-Cruz
Mar 21, 2016·Mutation Research·M Monserrat Pacheco-MartínezRocío Ortiz-Muñiz
Jan 29, 2002·Environmental and Molecular Mutagenesis·C GonzálezR Ortiz

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