Analysis of Mlc-lacZ Met mutants highlights the essential function of Met for migratory precursors of hypaxial muscles and reveals a role for Met in the development of hyoid arch-derived facial muscles

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Chiara PrunottoCarola Ponzetto

Abstract

The Pax3 and c-met genes are necessary for the development of tongue, diaphragm, and limb muscles. These hypaxial muscles derive from precursors that migrate out of the ventrolateral lip of the somites at occipital, cervical, and limb levels. In this work, we re-examined primary myogenesis in c-met signaling mutants using a skeletal muscle-specific lacZ transgene (Mlc3f-nlacZ-2E). This strategy allowed us to identify precisely the shoulder, limb, tongue, and dermal muscles that need Met for development and to confirm that the morphological structure of epaxial and body wall muscles was normal, even in the most severe c-met mutant. Surprisingly, however, X-gal staining showed that, in this mutant, hyoid arch-derived facial muscles were either reduced or absent, thus revealing that Met also contributes to the development of muscles in the head.

References

May 1, 1995·Anatomy and Embryology·B Christ, C P Ordahl
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·J A EpsteinR L Maas
Apr 13, 1999·Cell and Tissue Research·S Dietrich
Apr 13, 1999·Cell and Tissue Research·B Brand-Saberi, B Christ
Nov 7, 2000·Current Opinion in Cell Biology·C Birchmeier, H Brohmann
Jul 13, 2001·Current Opinion in Genetics & Development·M Buckingham
Feb 12, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Osamu AmanoShoichi Iseki
Feb 18, 2003·Journal of Anatomy·Margaret BuckinghamFrédéric Relaix

❮ Previous
Next ❯

Citations

Oct 18, 2006·Anatomy and Embryology·Darrell J R EvansKetan Patel
May 6, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Paolo Emanuele ForniSusan Wray
Nov 2, 2014·Biological Reviews of the Cambridge Philosophical Society·Masayoshi Tokita
Nov 22, 2008·Evolution & Development·Marianne DeriesMarilyn J Duxson
Feb 28, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Drew M Noden, Philippa Francis-West
Dec 30, 2006·The Journal of Biological Chemistry·Tiziana CrepaldiCarola Ponzetto
Mar 7, 2020·British Journal of Pharmacology·Simona GalloTiziana Crepaldi
Jun 23, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Rui Diogo, Janine M Ziermann
Aug 22, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Rui DiogoJanine M Ziermann
Dec 18, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Qin PuBeate Brand-Saberi
Jun 11, 2020·Seminars in Cell & Developmental Biology·Françoise Helmbacher, Sigmar Stricker
Feb 5, 2008·Developmental Biology·Hong-Ming ZhouSimon J Conway
Dec 15, 2006·Gene Expression Patterns : GEP·Hung Ping ShihChrissa Kioussi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.