Analysis of monoamine oxidase A (MAOA) promoter polymorphism in Finnish male alcoholics

Psychiatry Research
Takuya SaitoJari Tiihonen

Abstract

Alterations in monoamine oxidase A (MAOA) expression and enzyme activity may be associated with alcoholism and impulsive behavior. Therefore, functional polymorphisms in the MAOA gene would be good candidates to consider in the interindividual differences that exist in the susceptibility to alcoholism. One variant that has been considered as a candidate in alcoholism is a repeat polymorphism in the MAOA gene promoter. We analyzed a cohort of Finnish males with either type 1 or type 2 alcoholism, as well as controls, for differences in the distribution of MAOA promoter alleles. Based on other studies, we postulated that type 2 alcoholism, which is associated with antisocial behavior, but not type 1 alcoholism, would be correlated with the inheritance of the low promoter activity allele. However, we failed to find a difference in allele distribution in type 1 and type 2 alcoholics. In addition, there was no difference in the allele distribution when each group of alcoholics was compared with controls. However, when both groups of alcoholics were pooled and compared with controls, the difference in allele distribution reached a trend towards significance. Our results suggest a minimal association between the MAOA low activity prom...Continue Reading

References

Feb 1, 1990·Psychological Medicine·K R Merikangas
Sep 1, 1990·Journal of Studies on Alcohol·W R YatesM W Kelly
Apr 15, 1990·Biological Psychiatry·J L SullivanJ S Holmes
Apr 24, 1987·Science·C R Cloninger
Dec 1, 1986·Archives of General Psychiatry·R J CadoretE Heywood
Jun 1, 1971·The American Journal of Psychiatry·M L Selzer
Dec 15, 1993·American Journal of Medical Genetics·E J DevorB Tabakoff
Oct 9, 1995·American Journal of Medical Genetics·A ParsianC R Cloninger
Aug 7, 1998·Journal of Psychiatric Research·C K FarrenT G Dinan
Nov 3, 1998·Human Genetics·S Z SabolD Hamer

❮ Previous
Next ❯

Citations

Aug 26, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S CevoliP Montagna
Oct 2, 2008·Archives of Women's Mental Health·Camilla GokturkJarmila Hallman
Mar 9, 2011·Archives of General Psychiatry·Nelly Alia-KleinRita Z Goldstein
Aug 8, 2008·Carcinogenesis·Zhizhong ZhangZhengdong Zhang
Oct 10, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ming-Chuan HuRu-Band Lu
Mar 12, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jaanus Harro, Lars Oreland
Feb 8, 2005·Journal of the Neurological Sciences·Vedrana FilicBranimir Jernej
Aug 3, 2007·Biochemical Pharmacology·Michael D Köhnke
May 6, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Robert A PhilibertAnup Madan
Dec 21, 2012·Neuroscience and Biobehavioral Reviews·Scott Mackey, Martin Paulus
Mar 2, 2013·The International Journal of Neuropsychopharmacology·Philippe A MelasCatharina Lavebratt
Mar 27, 2015·International Journal of Environmental Research and Public Health·Agnieszka SamochowiecAnna Grzywacz
Feb 3, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Michael M VanyukovRobert E Ferrell
May 20, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yung-Yu HuangJ John Mann
Jan 30, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Abbas ParsianZhen Hua Zhang
Mar 10, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Verônica ContiniClaiton H D Bau
Apr 12, 2007·Journal of Neural Transmission·L OrelandJ Hallman
Apr 19, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Guang GuoNathan Hamilton
May 19, 2005·Psychiatric Genetics·Camila GuindaliniMayana Zatz
Feb 14, 2007·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Ian W Craig
Jan 8, 2020·Molecular Psychiatry·Benoit LabontéGustavo Turecki
Dec 1, 2017·Trends in Cognitive Sciences·Russell A PoldrackJoshua W Buckholtz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.