Analysis of MTR and MTRR Polymorphisms for Neural Tube Defects Risk Association

Medicine
Yongxin WangZengliang Wang

Abstract

Neural tube defects (NTDs) are the most common congenital defects of the central nervous system among neonates and the folate status during pregnancy was considered as the most important etiopathogenesis of NTDs. Besides, methionine synthase (MTR) gene and methionine synthase reductase (MTRR) gene were folate metabolism involved genes and had been investigated in several previous studies with inconsistent results. Hence, we aimed to explore the association of 4 selected single-nucleotide polymorphisms (SNPs) on MTRR/MTR gene and the susceptibility of NTDs in a Chinese population.Seven SNPs were selected from HapMap databases with Haploview 4.2 software. A polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed to genotype the polymorphisms from blood samples of 165 NTDs patients and 280 healthy controls. The correlation between these SNPs and NTDs risk was tested by Student t test and Chi-square test by STATA 11.0 software. Furthermore, we performed a meta-analysis of relevant studies to investigate the association between the SNPs MTRR 66A>G and MTR 2756A>G and the susceptibility of NTDs.An increased risk of NTDs was verified to be significantly associated with MTRR 66A>G (G allele vs. A all...Continue Reading

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Citations

Feb 3, 2018·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Yulian FangChunquan Cai
Sep 26, 2017·American Journal of Medical Genetics. Part a·Kit Sing AuHope Northrup
Jun 20, 2017·Annual Review of Nutrition·Anne M MolloyLawrence C Brody

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Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

STATA
Haploview
Primer Premier

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