Analysis of multiple metabolomic subsets in vitro: methodological considerations

Toxicology Mechanisms and Methods
M S YangR C Gupta

Abstract

Abstract Metabolomic analysis is a technology which seeks to provide a comprehensive profile of all the metabolites present in a biological sample ( Fiehn 2002 ; Noguchi et al. 2003 ; Watkins et al. 2002 ). Metabolomics is not a new science, but emerging as an exciting application which can span the scope of biotechnology and medicine, providing metabolic profile and a complement to the genomic and proteomic data ( German et al. 2003 ). Studies have already begun to explore the effects of toxicological, pharmaceutical, nutritional, and environmental intervention and to build integrated databases of metabolite concentrations throughout biological systems, ranging from microbes to plants to human and research animal populations ( Bruskiewich et al. 2003 ; Bailey et al. 2003 ; Fiehn 2003 ; Novotna et al. 2003 ). This may provide a tool for discovering a novel pathway, or determining the relationship of these metabolite concentrations to disease, and the extent to which nutrition can modulate metabolite concentrations ( Weckwerth and Fiehn 2002 ). Metabolites are the products of enzymatic processes. Their levels can be regarded as the ultimate response of biological systems to genetic or environmental changes ( Fiehn 2002 ). While ...Continue Reading

References

Sep 1, 1968·The American Journal of Physiology·P NeedlemanO H Lowry
Sep 1, 1966·Archives of Neurology·W W TourtellotteM J Rowe
Jun 1, 1967·Journal of Neurochemistry·L J KingS Wilson
Nov 1, 1983·Journal of Neurochemistry·M S YangR L Hayes
Aug 1, 1994·Bulletin of Environmental Contamination and Toxicology·A Castaño, J V Tarazona
May 20, 1999·Annual Review of Pharmacology and Toxicology·T P DaltonA Puga
Jul 15, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·B HultbergA Isaksson
Jan 21, 2000·Free Radical Biology & Medicine·W G KirlinD P Jones
Mar 12, 2002·Methods in Enzymology·Carole Kretz-Remy, André-Patrick Arrigo
Mar 12, 2002·Methods in Enzymology·Dean P Jones
Apr 16, 2002·Current Opinion in Biotechnology·Wolfram Weckwerth, Oliver Fiehn
Jun 22, 2002·Brain : a Journal of Neurology·Fiona M MenziesPamela J Shaw
Jun 22, 2002·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Edward FelderWalter Pfaller
Oct 16, 2002·Drug and Chemical Toxicology·Nicholas V Reo
Dec 3, 2002·Current Opinion in Biotechnology·Steven M Watkins, J Bruce German
Dec 10, 2002·Combinatorial Chemistry & High Throughput Screening·Lora C RoboskyMichael D Reily
Feb 19, 2003·Phytochemistry·Oliver Fiehn
May 29, 2003·The Journal of Nutrition·J Bruce GermanSteven M Watkins
May 29, 2003·The Journal of Nutrition·Yasushi NoguchiTakeshi Kimura
Jul 12, 2003·Bioinformatics·Richard M BruskiewichChristopher Graham McLaren
Jan 1, 2003·Toxicology Mechanisms and Methods·Mildred S Yang, Ramesh C Gupta
Jan 1, 2003·Toxicology Mechanisms and Methods·M S Yang, Ramesh C Gupta
Jan 1, 2000·Pflügers Archiv : European journal of physiology·Ramesh C GuptaWolf-D Dettbarn

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Related Papers

The British Journal of Nutrition
Phillip D WhitfieldPeter-John M Noble
Current Opinion in Biotechnology
Marshall Louis Reaves, Joshua D Rabinowitz
Drug Discovery Today
Miroslava Cuperlović-CulfIan Chute
Advances in Nutrition
Monique LeMieuxNaima Moustaid-Moussa
© 2022 Meta ULC. All rights reserved