Analysis of mutations within the 5' untranslated region, interferon sensitivity region, and PePHD region as a function of response to interferon therapy in hepatitis C virus-infected patients in India

Journal of Clinical Microbiology
Romi GuptaSaumitra Das

Abstract

Mutations in several subgenomic regions have been implicated in influencing response to interferon therapy; however, a comprehensive picture of Indian patients was lacking. Based on the viral load and clinical factors, 10 out of 15 patients were found to be complete responders, whereas 5 patients were nonresponders. The pretreatment viral RNA load of the patients was found to be between 5.20 and 6.13 log10 IU/ml, which eventually fell to 2.77 log10 IU/ml after 24 weeks of treatment, whereas in the case of nonresponders, the average was 5.38 log10 IU/ml. In order to study the influence of the hepatitis C virus genotype on the response to interferon therapy, the 5' untranslated region sequences of the samples were analyzed, which showed that genotype 3 patients responded better than genotype 1 patients. Additionally, the mutations in the interferon sensitivity-determining region (ISDR) of the NS5A protein and the double-stranded RNA-activated protein kinase-eukaryotic initiation factor 2 alpha phosphorylation homology domain (PePHD) of the E2 envelope protein, before and after treatment, were compared with nonresponder prototype J. Although, no clear correlation was found in the case of the mutated ISDR, some significant changes ...Continue Reading

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Citations

May 9, 2008·PloS One·Nathan A CannonUNKNOWN Virahep-C Study Group
Mar 31, 2009·Future Microbiology·Claudio ArgentiniMaria Rapicetta
Jan 22, 2008·World Journal of Gastroenterology : WJG·Deepak KumarPremashis Kar
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Mar 18, 2015·Evolutionary Bioinformatics Online·Alicia Amadoz, Fernando González-Candelas

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