Analysis of nerve agents using capillary electrophoresis and laboratory-on-a-chip technology

Journal of Chromatography. a
Martin Pumera

Abstract

The nerve agents belong among the most toxic compounds produced by human kind. While they have been used very sporadically until now, typically in local conflicts or by local terrorists groups, the global increase in terrorist activity in the recent years has generated tremendous demand for innovative tools capable of detecting nerve agents. Fast, sensitive and reliable detection of nerve agents in the field is very important issue in present days. Capillary electrophoresis (CE) offers great possibilities for sensitive detection of these harmful compounds as well as incorporation in mobile laboratory and it proved to have capability to detect nerve agent breakdown products in real environmental samples. Laboratory-on-a-chip format offers great possibilities to create portable, field deployable, rapidly responding and potentially disposable device, allowing security forces to make the important decision regarding the safety of civilians. This article overviews the conventional capillary electrophoretic and laboratory-on-a-chip techniques for analysis of degradation products of G-type and V-type nerve agents. It discusses diverse strategies of detection of different nerve agents breakdown products, which are corresponding to thei...Continue Reading

References

Dec 20, 2002·Journal of Chromatography. a·Edwin W J HooijschuurUdo A Th Brinkman
Nov 27, 2004·Electrophoresis·Walter R VandaveerSusan M Lunte

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Citations

Mar 16, 2007·Analytical and Bioanalytical Chemistry·Douglas D Richardson, Joseph A Caruso
Jun 19, 2012·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Charlotte DesoubriesValérie Pichon
Jun 25, 2008·Analytica Chimica Acta·Cui LiuXie Zhou
Sep 12, 2012·Electrophoresis·Eric T da CostaClaudimir Lucio do Lago
May 24, 2008·Lab on a Chip·Hsih Yin TanNam-Trung Nguyen
Aug 23, 2011·The Analyst·Svetlana S AleksenkoAndrei R Timerbaev
Jan 1, 2016·Environmental Chemistry Letters·Imran AliMohd Marsin Sanagi
Aug 8, 2017·Analytical Chemistry·Cavin TanMartin Pumera

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