Analysis of nitrosamines in wastewater: exploring the trace level quantification capabilities of a hybrid linear ion trap/orbitrap mass spectrometer

Analytical Chemistry
Martin Krauss, Juliane Hollender

Abstract

A method was developed to determine nine N-nitrosamines in wastewater on the basis of solid-phase extraction and liquid chromatography mass spectrometry using a linear ion trap-orbitrap hybrid instrument at high mass resolution. Analytes and five deuterated internal standards were preconcentrated by solid-phase extraction. Positive electrospray ionization resulted in protonated molecular ions of all nitrosamines. One to three product ions were formed by collision-induced dissociation or higher energy C-trap dissociation. The signal intensity of the product ions differed up to a factor of 3 between the two techniques. The molecular ions were usually used for quantification, because of the better sensitivity, and the product ions for confirmation. An actual mass resolving power of 25 000-40 000 ensured a sufficient selectivity to distinguish all molecular and product ions from interfering background ions. Only for N-nitrosomorpholine was a coeluting isobaric molecular ion detected in wastewater samples, which, however, formed different product ions. The mass accuracy was between -12 ppm at m/z 55 and 0 ppm at m/z 205 and did not change for more than 5 ppm over a sample sequence of 20 h analysis time. The optimized method allowed ...Continue Reading

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Citations

Mar 17, 2010·Analytical and Bioanalytical Chemistry·Martin KraussJuliane Hollender
Nov 11, 2010·Analytical and Bioanalytical Chemistry·Despo Fatta-KassinosAnastasia Nikolaou
Mar 1, 2012·Analytical and Bioanalytical Chemistry·F HernándezL Mattioli
Feb 24, 2012·Applied Microbiology and Biotechnology·Klaus FischerChristian Zwiener
Mar 5, 2013·Environmental Science and Pollution Research International·Ana AgüeraAmadeo R Fernández-Alba
Sep 11, 2014·Journal of Hazardous Materials·Félix HernándezFrancisco J López
Jan 20, 2016·International Journal of Molecular Sciences·Lucy LimDavid Klein
Mar 8, 2016·American Journal of Analytical Chemistry·James A HodgsonLanqing Wang
Mar 1, 2011·Journal of Hazardous Materials·Jacek Nawrocki, Przemysław Andrzejewski
Jul 18, 2009·Water Research·Martin KraussJuliane Hollender
Mar 17, 2009·The Science of the Total Environment·Mari AsamiKoji Kosaka
Aug 13, 2008·Analytical Biochemistry·Patrick KieferJulia A Vorholt
Dec 30, 2008·Journal of Biochemical and Molecular Toxicology·S A SheweitaH M Al-Masry
Aug 8, 2008·Mass Spectrometry Reviews·Richard H PerryRobert J Noll
Sep 4, 2015·Environmental Science & Technology·Wenhui GanPaul Westerhoff
Apr 14, 2016·Journal of Hazardous Materials·Adam J GushgariArjun K Venkatesan
Jun 9, 2016·Journal of Analytical Toxicology·James A HodgsonLanqing Wang
Jul 28, 2016·Journal of Colloid and Interface Science·Maryam Lashgari, Hian Kee Lee
Feb 4, 2010·Journal of Separation Science·Beatriz Jurado-SánchezMercedes Gallego
Apr 15, 2010·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Virender K Sharma
Jun 6, 2014·Environmental Science. Processes & Impacts·Sofia LindahlElsa Lundanes
Apr 1, 2016·Journal of Food and Drug Analysis·Xueli LiQiang He
Jan 7, 2009·Journal of Chromatography. a·Beatriz Jurado-SánchezMercedes Gallego
Jun 19, 2009·Environmental Science & Technology·Lokesh PadhyeChing-Hua Huang
May 8, 2010·Environmental Science & Technology·Lokesh PadhyeChing-Hua Huang
Sep 21, 2010·Environmental Science & Technology·Martin KraussJuliane Hollender

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