PMID: 16502654Mar 1, 2006Paper

Analysis of nonlinear coupled diffusion of oxygen and lactic acid in intervertebral discs

Journal of Biomechanical Engineering
Dahbia Mokhbi SoukaneJ P Urban

Abstract

The transport of oxygen and lactate (i.e., lactic acid) in the human intervertebral disc was investigated accounting for the measured coupling between species via the pH level in the tissue. Uncoupled cases were also analyzed to identify the extent of the effect of such coupling on the solute gradients across the disc. Moreover, nonlinear lactic production rate versus lactic concentration and oxygen consumption rate versus oxygen concentration were considered. The nonlinear coupled diffusion equations were solved using an in-house finite element program and an axisymmetric model of the disc with distinct nucleus and anulus regions. A pseudotransient approach with a backward integration scheme was employed to improve convergence. Coupled simulations influenced the oxygen concentration and lactic acid concentration throughout the disc, in particular the gradient of concentrations along the disc mid-height to the nucleus-anulus boundary where the solutes reached their most critical values; minimum for the oxygen tension and maximum for the lactate. Results suggest that for realistic estimates of nutrient and metabolite gradients across the disc, it could be important to take into account the coupling between the rates of synthesis...Continue Reading

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Citations

Nov 19, 2008·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·D Mokhbi SoukaneJ P G Urban
Feb 22, 2011·Computer Methods in Biomechanics and Biomedical Engineering·Alicia R JacksonWei Yong Gu
Oct 6, 2011·Computer Methods in Biomechanics and Biomedical Engineering·Fabio GalbuseraCornelia Neidlinger-Wilke
Sep 29, 2011·The Orthopedic Clinics of North America·Thijs GrunhagenJill P G Urban
Mar 6, 2007·Journal of Biomechanics·D Mokhbi SoukaneJ P G Urban
May 12, 2009·Annals of the New York Academy of Sciences·D B DasO A Boubriak
Apr 1, 2009·Arthritis and Rheumatism·Thorsten GuehringJill P G Urban
Nov 7, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Shigeru KobayashiJill Urban
Aug 30, 2008·Biotechnology and Bioengineering·Shengda ZhouJill P G Urban
Jul 4, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Feng-Lai YuanJian Dong
May 27, 2014·Journal of Biomechanics·Francesco TravascioShihab Asfour
Mar 23, 2011·Computer Methods in Biomechanics and Biomedical Engineering·K M Louman-GardinerC J Hunter
Nov 26, 2015·Cellular and Molecular Bioengineering·Jennifer Rico-VarelaMaribel Vazquez
Apr 6, 2006·The Journal of Bone and Joint Surgery. American Volume·Thijs GrunhagenJill P G Urban
Jan 16, 2021·International Journal of Molecular Sciences·Laura BaumgartnerJérôme Noailly

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