Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study.

Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
Stéphane CauchiD.E.S.I.R. Study Group

Abstract

Recently, Genome Wide Association (GWA) studies identified novel single nucleotide polymorphisms (SNPs), highly associated with type 2 diabetes (T2D) in several case-control studies of European descent. However, the impact of these markers on glucose homeostasis in a population-based study remains to be clarified. The French prospective D.E.S.I.R. study (N = 4,707) was genotyped for 22 polymorphisms within 14 loci showing nominal to strong association with T2D in recently published GWA analyses (CDKAL1, IGFBP2, CDKN2A/2B, EXT2, HHEX, LOC646279, SLC30A8, MMP26, KCTD12, LDLR, CAMTA1, LOC38776, NGN3 and CXCR4). We assessed their effects on quantitative traits related to glucose homeostasis in 4,283 normoglycemic middle-aged participants at baseline and their contribution to T2D incidence during 9 years of follow-up. Individuals carrying T2D risk alleles of CDKAL1 or SLC30A8 had lower fasting plasma insulin level (rs7756992 P = 0.003) or lower basal insulin secretion (rs13266634 P = 0.0005), respectively, than non-carriers. Furthermore, NGN3 and MMP26 risk alleles associated with higher fasting plasma glucose levels (rs10823406 P = 0.01 and rs2499953 P = 0.04, respectively). However, for these SNPs, only modest associations were fo...Continue Reading

References

Mar 10, 2004·The International Journal of Biochemistry & Cell Biology·Natalia D MarchenkoAlex Y Strongin
Sep 13, 2005·Nature Medicine·Fan-Yan WeiKazuhito Tomizawa
Sep 15, 2005·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Fabrice ChimientiMichel Seve
Oct 11, 2005·Lancet·Andrew T Hattersley, Mark I McCarthy
Mar 3, 2006·The EMBO Journal·Georg MellitzerHarry Heimberg
Sep 8, 2006·Nature·Janakiraman KrishnamurthyNorman E Sharpless
Apr 27, 2007·Nature Genetics·Valgerdur SteinthorsdottirKari Stefansson
Apr 28, 2007·Science·UNKNOWN Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical RShaun Purcell
Aug 19, 2007·Nature Reviews. Genetics·Timothy M Frayling

❮ Previous
Next ❯

Citations

Oct 21, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Benedicte Fontaine-BissonPierre-Emmanuel Morange
Aug 13, 2008·Diabetologia·T Jin
Oct 13, 2009·Diabetes, Obesity & Metabolism·N WijesekaraM B Wheeler
Jun 23, 2010·Genetics and Molecular Research : GMR·M A S DehwahQ-Y Huang
Feb 20, 2010·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Y L JingD L Zhu
May 16, 2009·The Journal of Nutritional Biochemistry·Judith JansenLothar Rink
Sep 29, 2011·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Lindsay A MillerRonald A Cohen
Dec 19, 2013·Diabetic Medicine : a Journal of the British Diabetic Association·M LucianoI J Deary
Mar 13, 2014·Pediatrics International : Official Journal of the Japan Pediatric Society·Taketoshi YoshidaToshio Miyawaki
Jan 16, 2010·Cell Metabolism·Kristina HedbackerJeffrey M Friedman
Feb 9, 2010·Molecular Genetics and Metabolism·Stéphane CauchiPiero Marchetti
May 26, 2004·Endocrinology and Metabolism Clinics of North America·Adrian J CameronPaul Z Zimmet
Feb 11, 2010·Journal of Diabetes Science and Technology·Steven C Elbein
May 19, 2012·Nature Reviews. Neuroscience·Martin Gassmann, Bernhard Bettler
Jun 15, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Kalliopi I PappaAristides Antsaklis
Mar 27, 2012·Endocrine Journal·Eiji Kawasaki
Apr 30, 2019·Basic & Clinical Pharmacology & Toxicology·Thorsten Fritzius, Bernhard Bettler
Aug 6, 2009·BioFactors·Dimitry A Chistiakov, Natalia V Voronova
Feb 14, 2019·Inflammopharmacology·Tianjiao ZhaoWei Wei
Apr 3, 2019·International Journal of Endocrinology·Qiong HuangZhicheng Gong

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.