Analysis of nucleic acids by FTICR MS

Mass Spectrometry Reviews
S A HofstadlerJ C Hannis

Abstract

Fourier transform ion cyclotron resonance (FTICR) mass spectrometry represents a unique platform with which to study nucleic acids and non-covalent complexes containing nucleic acids moieties. In particular, systems in which very high mass measurement accuracy is required, very complex mixtures are to be analyzed, or very limited amounts of sample are available may be uniquely suited to interrogation by FTICR mass spectrometry. Although the FTICR platform is now broadly deployed as an integral component of many high-end proteomics-based research efforts, momentum is still building for the application of the platform towards nucleic acid-based analyses. In this work, we review fundamental aspects of nucleic acid analysis by FTICR, focusing primarily on the analysis of DNA oligonucleotides but also describing applications related to the characterization of RNA constructs. The goal of this review article is to give the reader a sense of the breadth and scope of the status quo of FTICR analysis of nucleic acids and to summarize a few recently published reports in which researchers have exploited the performance attributes of FTICR to characterize nucleic acids in support of basic and applied research disciplines including genotypin...Continue Reading

References

Apr 1, 1992·Rapid Communications in Mass Spectrometry : RCM·J A CastroC Wilkins
Sep 1, 1993·Rapid Communications in Mass Spectrometry : RCM·E A StemmlerM V Buchanan
Jul 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·X ChengR D Smith
Jun 1, 1996·Journal of Mass Spectrometry : JMS·Q WuR D Smith
Nov 1, 1996·Journal of Mass Spectrometry : JMS·M G BartlettR H Griffey
Mar 21, 1998·Current Opinion in Biotechnology·P F Crain, J A McCloskey
Sep 16, 1998·Analytical Chemistry·J M RobinsonD A Laude
Oct 30, 1998·Journal of the American Society for Mass Spectrometry·J S KlassenE R Williams
Dec 8, 1998·Rapid Communications in Mass Spectrometry : RCM·K Sannes-LoweryS A Hofstadler
Jun 15, 1999·Analytical Chemistry·S A HofstadlerR H Griffey
Sep 1, 1999·Proceedings of the National Academy of Sciences of the United States of America·R H GriffeyS T Crooke
Jan 13, 2000·Journal of the American Society for Mass Spectrometry·K A Sannes-Lowery, S A Hofstadler
Jan 3, 2001·Rapid Communications in Mass Spectrometry : RCM·S DaolioA Bellosi
Feb 24, 2001·Journal of the American Society for Mass Spectrometry·K X WanM L Gross

❮ Previous
Next ❯

Citations

Jul 31, 2009·Analytical and Bioanalytical Chemistry·Lutz F TietzeHolm Frauendorf
Jan 13, 2006·Journal of the American Society for Mass Spectrometry·Herbert OberacherWalther Parson
Jul 29, 2006·Journal of the American Society for Mass Spectrometry·Jiong Yang, Kristina Håkansson
Jun 24, 2008·Journal of the American Society for Mass Spectrometry·Kathrin BreukerFred W McLafferty
Oct 10, 2008·Journal of the American Society for Mass Spectrometry·Tak Wah Dominic ChanYi Man Eva Fung
Nov 10, 2009·Journal of the American Society for Mass Spectrometry·Daniele Fabris
Jan 26, 2006·Nucleic Acids Research·Robert J FisherAlan Rein
Sep 2, 2010·Microbiology and Molecular Biology Reviews : MMBR·W Ian Lipkin
Nov 1, 2013·Journal of the American Society for Mass Spectrometry·Majlinda KullolliSharon J Pitteri
Jul 31, 2012·International Journal of Legal Medicine·Katleen Van SteendamDieter Deforce
Sep 6, 2007·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Sarah E EvansVeronika A Szalai
May 4, 2013·Expert Review of Molecular Diagnostics·Lilia M Ganova-Raeva, Yury E Khudyakov
Dec 7, 2010·International Journal of Antimicrobial Agents·Michela PaolucciVittorio Sambri
Mar 28, 2008·Antiviral Research·Phenix-Lan QuanW Ian Lipkin
May 27, 2005·Journal of Mass Spectrometry : JMS·Herbert OberacherWalther Parson
Sep 16, 2009·Annals of the New York Academy of Sciences·W Ian LipkinThomas Briese
Feb 4, 2009·Biopolymers·Herbert Oberacher, Florian Pitterl
May 2, 2007·Mass Spectrometry Reviews·Liam A McDonnell, Ron M A Heeren
Nov 18, 2008·Rapid Communications in Mass Spectrometry : RCM·Cuihong WanShuying Liu
May 13, 2008·Rapid Communications in Mass Spectrometry : RCM·Yan ZouJerome Hochman
Jul 19, 2008·Mass Spectrometry Reviews·Xiaojun FengBi-Feng Liu
Mar 5, 2010·Mass Spectrometry Reviews·Michael B Beverly
Nov 17, 2010·Rapid Communications in Mass Spectrometry : RCM·Hélène ManduzioFrançois Fenaille
Nov 15, 2014·Journal of Mass Spectrometry : JMS·Siwei Li, Patrick A Limbach
Jan 9, 2014·Mass Spectrometry Reviews·Xiaojun FengXin Liu
May 1, 2007·Journal of Molecular Biology·Kevin B TurnerDaniele Fabris
Jun 10, 2010·European Journal of Mass Spectrometry·Herbert Oberacher
Nov 29, 2008·Organic & Biomolecular Chemistry·Alexey V UstinovMikhail S Shchepinov

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.