Analysis of octamer-binding transcription factors Oct2 and Oct1 and their coactivator BOB.1/OBF.1 in lymphomas

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Ana-Isabel SáezMiguel A Piris

Abstract

Oct1 and Oct2 are transcription factors of the POU homeo-domain family that bind to the Ig gene octamer sites, regulating B-cell-specific genes. The function of these transcription factors is dependent on the activity of B-cell-restricted coactivators such as BOB.1/OBF.1. Independent studies of the expression of these proteins in non-Hodgkin's lymphoma have been restricted to single markers, and most lack data concerning immunohistochemical expression. Thus, we have investigated the expression of Oct1, Oct2, and BOB.1/OBF.1 in human reactive lymphoid tissue and in a series of 140 Hodgkin and non-Hodgkin's lymphomas. None of these proteins was found to be restricted to B cells, although only B cells expressed high levels of all three markers. Additionally, germinal center B cells showed stronger Oct2 and BOB.1/OBF.1 staining. Consequently, most B-cell lymphomas showed reactivity for all three antibodies. Oct2 expression was significantly higher in germinal center-derived lymphomas, although other B-cell lymphomas also displayed a high level of Oct2 expression. Although T-cell lymphomas and Hodgkin's lymphomas expressed some of these proteins, they commonly exhibited less reactivity than B-cell lymphomas. Despite not being entire...Continue Reading

References

Oct 1, 1991·Trends in Genetics : TIG·H R Schöler
Jan 1, 1991·Annual Review of Immunology·L M Staudt, M J Lenardo
Oct 1, 1991·Molecular and Cellular Biology·C L MillerH Singh
Jan 11, 1991·Nucleic Acids Research·T WirthB Oeler
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·T G ParslowD K Granner
Oct 5, 1995·The New England Journal of Medicine·M HummelH Stein
Jan 26, 1995·Nature·M GstaigerC M Hovens
Feb 12, 2000·European Journal of Immunology·H LaumenT Wirth
Feb 29, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·C S MaloneR Wall
May 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S StevensR G Roeder
Jun 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S StevensR G Roeder

❮ Previous
Next ❯

Citations

Oct 14, 2003·Trends in Immunology·Michael A Teitell
Jul 17, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mónica García-CosíoCarmen Bellas
May 2, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Ryan C McCuneMohammad A Vasef
May 29, 2007·The American Journal of Surgical Pathology·Sandro SantagataJason L Hornick
Aug 27, 2011·Diagnostic Pathology·Tawatchai PongpruttipanSanya Sukpanichnant
May 19, 2006·American Journal of Clinical Pathology·Eric D HsiBrad Pohlman
Aug 25, 2004·American Journal of Clinical Pathology·David M DorfmanLaurie H Glimcher
Aug 11, 2007·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Hajime KurodaShinji Itoyama
Jan 17, 2013·Revista brasileira de hematologia e hemoterapia·Gisele Rodrigues GouveiaJuliana Pereira
May 21, 2009·Leukemia & Lymphoma·Graham W SlackLawrence R Zukerberg
Jan 7, 2006·Leukemia & Lymphoma·Maria BaiPanagiotis Kanavaros
Aug 30, 2006·American Journal of Clinical Pathology·Peiguo G ChuLawrence M Weiss
Mar 10, 2011·International Journal of Cancer. Journal International Du Cancer·Daisuke ObinataSatoshi Inoue
Feb 16, 2005·Human Pathology·David M DorfmanLaurie H Glimcher
Jan 6, 2005·The American Journal of Pathology·Cigdem AtayarAnke van den Berg
Apr 16, 2016·European Journal of Immunology·Keiji YamashitaShingo Ichimiya
Jul 7, 2009·International Journal of Surgical Pathology·Smita KrishnamurthyFriederike H Kreisel
Sep 22, 2017·Nucleic Acids Research·Enrique Carrillo-de-Santa-PauUNKNOWN BLUEPRINT Consortium
Jan 2, 2007·Advances in Anatomic Pathology·Maurilio PonzoniClaudio Doglioni
Jun 29, 2005·Histopathology·J F GarcíaM A Piris
Jul 10, 2020·Journal of Clinical and Experimental Hematopathology : JCEH·Akio SakataniTadashi Yoshino
Mar 23, 2017·Epigenomics·Jung Min ShimAndrew L Durham
Mar 10, 2016·International Journal of Surgical Pathology·Anuj VermaShripad Banavali
Feb 13, 2003·American Journal of Clinical Pathology·Patricia UherovaWilliam G Finn
Jun 16, 2021·Journal of the Egyptian National Cancer Institute·Anurag MehtaSunil Pasricha

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.