Analysis of Osteoclastogenesis/Osteoblastogenesis on Nanotopographical Titania Surfaces

Advanced Healthcare Materials
Robert K SilverwoodPenelope M Tsimbouri

Abstract

A focus of orthopedic research is to improve osteointegration and outcomes of joint replacement. Material surface topography has been shown to alter cell adhesion, proliferation, and growth. The use of nanotopographical features to promote cell adhesion and bone formation is hoped to improve osteointegration and clinical outcomes. Use of block-copolymer self-assembled nanopatterns allows nanopillars to form via templated anodization with control over height and order, which has been shown to be of cellular importance. This project assesses the outcome of a human bone marrow-derived co-culture of adherent osteoprogenitors and osteoclast progenitors on polished titania and titania patterned with 15 nm nanopillars, fabricated by a block-copolymer templated anodization technique. Substrate implantation in rabbit femurs is performed to confirm the in vivo bone/implant integration. Quantitative and qualitative results demonstrate increased osteogenesis on the nanopillar substrate with scanning electron microscopy, histochemical staining, and real-time quantitative reverse-transcription polymerase chain reaction analysis performed. Osteoblast/osteoclast co-culture analysis shows an increase in osteoblastogenesis-related gene expressio...Continue Reading

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Citations

Sep 27, 2016·Acta Biomaterialia·Sander DobbengaAmir A Zadpoor
Nov 24, 2018·Advanced Healthcare Materials·Carlos Mas-MorunoMatthew J Dalby
Feb 26, 2019·Nanotechnology·Dwisetya S WidyaratihAmir A Zadpoor
Aug 8, 2018·Journal of Tissue Engineering·Wich OrapiriyakulPenelope M Tsimbouri
Jul 24, 2018·Journal of Tissue Engineering·Christopher AllanR M Dominic Meek
Aug 31, 2018·Journal of the Royal Society, Interface·Hannah DonnellyMatthew J Dalby
Oct 27, 2020·Bioactive Materials·Yogambha RamaswamyHala Zreiqat
Nov 27, 2020·International Journal of Nanomedicine·Haiyan WangJing Guo
Apr 20, 2021·Biomedical Materials·Ayomiposi M LoyeThemis R Kyriakides
Sep 26, 2019·The Journal of Physical Chemistry. B·Tianqing LiuShui Guan

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