Abstract
Multiple Endocrine Neoplasia type 1 (MEN1) is a hereditary disease characterised by the occurrence of multiple endocrine tumours. The biological functions of the responsible gene, MEN1, and its encoded protein, menin, remain so far largely elusive. The recent generation of Men1 mutant mice by our group and other laboratories provides powerful tools allowing for the identification of cellular and molecular events that occur after gene disruption. Interestingly, it has been recently reported that p27(Kip1) expression is regulated by menin and that decreased p27(Kip1) expression can be found in MEN1 insulinomas and parathyroid adenomas. In order to address whether and when p27(Kip1) expression alters during insulinoma development in pancreatic beta-cell-specific Men1 mutant mice, we analysed p27(Kip1) expression in islet lesions from mutant mice at different ages. Our data revealed that p27(Kip1) protein expression was reduced in 40 out of 52 (77%) insulinomas analysed, whereas the remaining 12 insulinomas (23%) did not show altered p27(Kip1) expression. No difference between the insulinomas with and without decreased p27(Kip1) expression could be observed in terms of histological features or menin inactivation. Furthermore, our a...Continue Reading
References
Jul 1, 1997·Human Molecular Genetics·S K AgarwalS J Marx
Apr 16, 1998·American Journal of Human Genetics·J H BassettR V Thakker
Aug 26, 1998·The Journal of Clinical Endocrinology and Metabolism·F FarneboC Larsson
Feb 16, 1999·Cell·S K AgarwalA L Burns
Mar 10, 2000·International Journal of Cancer. Journal International Du Cancer·V WautotG Weber
Jul 27, 2000·Molecular and Cellular Biology·D S FranklinY Xiong
Feb 7, 2001·Proceedings of the National Academy of Sciences of the United States of America·J S CrabtreeF S Collins
Mar 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·H KajiG N Hendy
Apr 17, 2001·Biochemical and Biophysical Research Communications·N OhkuraK Yamaguchi
Aug 14, 2001·Biochemical and Biophysical Research Communications·I H LemmensK Kas
Aug 30, 2001·Oncogene·C HeppnerA L Burns
May 22, 2002·Endocrinology·Yoshitaka SayoToshihiko Ishida
Dec 3, 2002·Journal of Molecular Endocrinology·H NamihiraT Ishida
Jan 2, 2003·Molecular and Cellular Biology·Karen E SukhodoletsStephen J Marx
Mar 22, 2003·The Journal of Biological Chemistry·Hideaki SowaKazuo Chihara
Jun 24, 2003·Molecular Endocrinology·Philippe BertolinoChang-Xian Zhang
Jul 3, 2003·Cell·Shiaw Yih Lin, Stephen J Elledge
Aug 15, 2003·Molecular and Cellular Biology·Judy S CrabtreeFrancis S Collins
Oct 1, 2003·Journal of Molecular Biology·Maud FromagetMartine Cordier-Bussat
Mar 3, 2004·Molecular Cell·Christina M HughesMatthew Meyerson
Apr 3, 2004·Molecular and Cellular Biology·Christine A BiondiNicholas K Hayward
Jun 17, 2004·Molecular and Cellular Biology·Akihiko YokoyamaMichael L Cleary
Jan 11, 2005·Proceedings of the National Academy of Sciences of the United States of America·Thomas A MilneJay L Hess
Citations
Mar 21, 2008·Nature Reviews. Cancer·Isabel M ChuJoyce M Slingerland
Jul 11, 2006·Annual Review of Cell and Developmental Biology·Jeremy J HeitSeung K Kim
Jul 29, 2010·BMC Cancer·Christelle SeigneLucien Frappart
Jul 1, 2009·Endocrine Journal·Akihiro SakuraiYoshimitsu Fukushima
Sep 12, 2015·Epigenomics·Alexandre How-KitJörg Tost
Sep 7, 2007·Clinical Endocrinology·Daniel LindbergGunnar Westin
Apr 4, 2016·Endocrine·Simona BorsariFilomena Cetani
Dec 23, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Nader HusseinChang X Zhang
Feb 27, 2016·PloS One·Avigail Dreazen WittenbergOded Meyuhas
Jan 21, 2017·Cell Death and Differentiation·Peng LiuJan P Tuckermann
Jun 2, 2018·International Journal of Endocrinology·Adriana Graciela DíazOscar D Bruno
Nov 15, 2017·Journal of Endocrinological Investigation·E B ConemansM R Vriens
Dec 28, 2010·Journal of Biotechnology·Lye T LockEmmanuel S Tzanakakis