Analysis of p53 expression in osteosarcoma of the jaw: correlation with clinicopathologic and DNA ploidy findings

Human Pathology
P OliveiraM O Almeida

Abstract

The objective of this study was to determine whether p53 expression correlated with clinicopathological and DNA ploidy in osteosarcoma of the jaw, a particular subtype of osteosarcoma associated with an older age at presentation, longer median survival, rare metastasis, and death due to uncontrolled local recurrence. Seventeen cases of osteosarcoma of the jaw were stained for p53 using CM1 antibody (Novocastra). Eight cases (47.5%) showed nuclear staining in more than 10% of the neoplastic nuclei. Ploidy analysis showed 13 aneuploid (eight p53+) and three diploid (none p53+) tumors. No significant relationship was found between p53 positivity and clinicomorphological features, DNA ploidy or survival. p53-positive cases were, however, more commonly associated with aneuploidy and chondroblastic differentiation. These results indicate that p53 immunostaining does not seem to provide prognostic information in osteosarcoma of the jaw.

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Citations

Nov 7, 2008·Veterinary Surgery : VS·Jolle KirpensteijnGerard R Rutteman
Jul 31, 2013·Histopathology·María Luisa PaparellaRómulo Luis Cabrini
May 16, 2003·Oral Oncology·Ademar Takahama JuniorMárcio Ajudarte Lopes
Mar 25, 2017·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Ben Tudor-GreenPeter A Brennan
Feb 9, 2018·The Journal of Craniofacial Surgery·Daniel GinatNicole Cipriani
Jun 20, 2008·Clinical Orthopaedics and Related Research·Ni TangTong-Chuan He
May 15, 2020·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Faizan MalikShweta Agarwal

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