Analysis of paralytic shellfish toxins in Aphanizomenon DC-1 from Lake Dianchi, China

Environmental Toxicology
Yongmei LiuLirong Song

Abstract

Lake Dianchi is in Yunnan Province in southwestern China. In recent years, significant cyanobacterial blooms have occurred in this lake nearly every year because of eutrophication. Monitoring data for the past 5 years acquired by our research group showed that phytoplankton composition alternated between species of Microcystis sp. during warm seasons and those of Aphanizomenon sp. during cool seasons. In March 2003, when phytoplankton composition was highly dominated by Aphanizomenon sp., samples were taken from the lake for toxin detection and immediate strain isolation. A mouse bioassay with extracts from the lyophilized field material showed obvious intoxication from paralytic shellfish poisons (PSPs), and all mice died within 30 min. Further analysis of both field and isolated algal strain Aphanizomenon DC-1 by the postcolumn HPLC-FLD method confirmed its PSP-producing ability. The analogues found in the extracts from the field material were neoSTX, dcSTX, and dcGTX3, with contents of 2.279, 1.135, and 0.547 ng/mg DW, respectively. Under laboratory culture condition, toxin content in the Aphanizomenon strain DC-1 varied greatly during different growth phases, with two peaks: in the early-exponential and late-stationary grow...Continue Reading

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Citations

Jan 27, 2010·Analytical and Bioanalytical Chemistry·A R HumpageS M Froscio
Jan 6, 2010·Applied and Environmental Microbiology·Andreas BallotClaudia Wiedner
Aug 18, 2010·Marine Drugs·Maria WieseBrett A Neilan
Mar 25, 2011·Journal of Toxicology and Environmental Health. Part a·David R RuebhartGeoffrey K Eaglesham
Jan 1, 2011·Leukemia Research and Treatment·Jeremy BechelliJane Liesveld
Oct 8, 2016·Environmental Toxicology and Pharmacology·Katie O'NeillAndrew Humpage
Feb 27, 2017·Toxicon : Official Journal of the International Society on Toxinology·Ekaterina ChernovaHanna Mazur-Marzec
Nov 25, 2018·Toxicon : Official Journal of the International Society on Toxinology·Paul M D'AgostinoSusanna A Wood
Aug 8, 2009·Toxicon : Official Journal of the International Society on Toxinology·Rómulo AráozNicole Tandeau de Marsac
Dec 1, 2021·Antonie van Leeuwenhoek·Yao XiaoBing-Huo Zhang

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