Analysis of Patient Characteristics and Risk Factors for Thrombosis After Surgery for Congenital Heart Disease

Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Lee D MurphyChristopher W Mastropietro

Abstract

Thrombosis is a cause of morbidity in 4-15% of children who undergo pediatric cardiac surgery. Data on how to prevent this complication are sorely needed. We aimed to identify risk factors for thrombosis following pediatric cardiac surgery and determine if use of low molecular weight heparin prophylaxis is associated with a reduction in thrombosis risk. Retrospective cohort study. Tertiary pediatric cardiovascular ICU. Patients who underwent cardiac surgery between June 2014 and December 2015. None. Data from patients with venous or arterial thrombosis confirmed by radiologic studies were matched two-to-one to controls based on age, Society of Thoracic Surgeons-European Association for Cardio-Thoracic Surgery mortality category, and gender. Thrombosis was detected in 33 patients (6.2%): 25 patients (76%) had venous thromboses, five patients (15%) had arterial thromboses, and three patients (9%) had both. Median time to thrombosis detection was 13 days (25-75%; 7-31 d). On multivariate analysis, which included adjustment for postoperative disease severity, fresh frozen plasma exposure was independently associated with thrombosis (odds ratio, 3.7; 95% CI, 1.4-9.4). Twenty-eight patients (85%) had central venous catheter-related t...Continue Reading

References

Oct 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·J PetäjäJ H Griffin
Oct 2, 2009·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Michael G GaiesJennifer C Hirsch
Mar 30, 2010·British Journal of Haematology·Vera IgnjatovicPaul Monagle
Jul 28, 2012·The Journal of Thoracic and Cardiovascular Surgery·Marshall L JacobsDavid R Clarke
Nov 15, 2013·Circulation·Therese M GigliaUNKNOWN American Heart Association Congenital Heart Defects Committee of the Council on Cardiovascular Disease in the Young, Council
May 8, 2014·Journal of Thrombosis and Haemostasis : JTH·E VidalE V S Faustino
Dec 10, 2014·Interactive Cardiovascular and Thoracic Surgery·Kyle G MileticChristopher W Mastropietro
Feb 9, 2016·American Journal of Surgery·Valerie EmuakhagbonChristopher M Jones
Oct 19, 2016·The Journal of Thoracic and Cardiovascular Surgery·Bradley SchererChristopher W Mastropietro
Sep 24, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Alexandra MarquezUNKNOWN Northeast Pediatric Critical Care Research Consortium
Feb 9, 2017·Frontiers in Pediatrics·Julie JaffrayPatti Massicotte
Apr 11, 2017·Paediatric Anaesthesia·Nina A Guzzetta, Glyn D Williams

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Citations

Nov 12, 2020·World Journal of Cardiology·Santosh KaipaMouhammad Yabrodi
May 6, 2021·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Isabelle SzepsAndreas Andersson
Jun 2, 2021·The Annals of Thoracic Surgery·Michael F SwartzJill M Cholette
Mar 22, 2020·Pediatrics·Brian S Donahue
Jan 7, 2022·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Jill M CholetteUNKNOWN Pediatric Critical Care Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding (TAXI-CAB), in collaborati

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