Abstract
To characterize the gene expression profile and determine potential diagnostic markers and therapeutic targets in pigmented villonodular synovitis (PVNS). Gene expression patterns in 11 patients with PVNS, 18 patients with rheumatoid arthritis (RA), and 19 patients with osteoarthritis (OA) were investigated using genome-wide complementary DNA microarrays. Validation of differentially expressed genes was performed by real-time quantitative polymerase chain reaction and immunohistochemical analysis on tissue arrays (80 patients with PVNS, 51 patients with RA, and 20 patients with OA). The gene expression profile in PVNS was clearly distinct from those in RA and OA. One hundred forty-one up-regulated genes and 47 down-regulated genes were found in PVNS compared with RA, and 153 up-regulated genes and 89 down-regulated genes were found in PVNS compared with OA (fold change > or = 1.5; Q < or = 0.001). Genes differentially expressed in PVNS were involved in apoptosis regulation, matrix degradation, and inflammation (ALOX5AP, ATP6V1B2, CD53, CHI3L1, CTSL, CXCR4, HSPA8, HSPCA, LAPTM5, MMP9, MOAP1, and SPP1). The gene expression signature in PVNS is similar to that of activated macrophages and is consistent with the local destructive c...Continue Reading
References
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R N Van GelderJ H Eberwine
Jan 7, 1998·Experimental Cell Research·R B KirkpatrickM Rosenberg
Jan 7, 1998·Genomics·A C KimA H Chishti
Oct 17, 1998·The Journal of Biological Chemistry·K DattaJ P Kehrer
Mar 14, 2000·The Journal of Biological Chemistry·M JonesD G Jackson
Mar 16, 2000·Proceedings of the National Academy of Sciences of the United States of America·D W VoehringerL A Herzenberg
May 10, 2000·Nature Genetics·M AshburnerG Sherlock
Nov 4, 2000·The Journal of Biological Chemistry·K O TanV C Yu
Nov 18, 2000·Archives of Pathology & Laboratory Medicine·L J LayfieldJ M Harrelson
Feb 28, 2001·The Journal of Molecular Diagnostics : JMD·M S RajeevanE R Unger
Apr 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·V G TusherG Chu
May 9, 2001·Nucleic Acids Research·M W Pfaffl
Aug 4, 2001·The Journal of Molecular Diagnostics : JMD·D Crisan
Aug 22, 2001·The Journal of Cell Biology·W WitkeF S Southwick
Jan 12, 2002·The Journal of Biological Chemistry·Shui-Ping WangBeth S Lee
Jan 17, 2002·Current Directions in Autoimmunity·M FeldmannR N Maini
Feb 15, 2002·Biological Chemistry·P O HackelA Ullrich
May 9, 2002·Biochimica Et Biophysica Acta·Michael G Walker
May 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·Robert TibshiraniGilbert Chu
Jul 12, 2002·Arthritis Research·Gillian MurphyIan Clark
Aug 10, 2002·Bioinformatics·Wolfgang HuberMartin Vingron
Feb 28, 2003·Oncogene·Mónica Yunta, Pedro A Lazo
Apr 16, 2003·Acta Obstetricia Et Gynecologica Scandinavica·Hannah DehnClaus K Høgdall
May 2, 2003·Arthritis Research & Therapy·David Naor, Shlomo Nedvetzki
Jul 17, 2003·The Journal of Clinical Investigation·Nobuchika YamamotoToshimitsu Uede
Oct 2, 2003·Genome Biology·Douglas A HosackRichard A Lempicki
Dec 3, 2003·Molecular Pathology : MP·S D JensonK S J Elenitoba-Johnson
Dec 19, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mark C GriffinDouglas K Trask
Jan 16, 2004·Oncogene·Weidong ZhaoVincent W Yang
Apr 1, 2004·Cell Biochemistry and Biophysics·Souad R SennouneRaul Martínez-Zaguilán
May 4, 2004·BMC Genomics·Jörg SchneiderHolger Sültmann
May 13, 2004·British Journal of Cancer·S R Rittling, A F Chambers
Jul 13, 2004·Seminars in Cancer Biology·Fran Balkwill
Aug 7, 2004·Annals of the Rheumatic Diseases·E-J A KrootJ M G W Wouters
Sep 9, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Caroline OspeltSteffen Gay
Apr 9, 2005·Arthritis and Rheumatism·J S SmolenUNKNOWN ATTRACT Study Group
Apr 22, 2005·Histopathology·I BergerF Autschbach
Citations
May 22, 2009·Der Orthopäde·I BergerV Krenn
Jul 30, 2010·Naunyn-Schmiedeberg's Archives of Pharmacology·Mahmoud YounsThomas Efferth
Dec 21, 2007·Cardiovascular and Interventional Radiology·Boris RadeleffGoetz M Richter
Aug 16, 2008·Cardiovascular and Interventional Radiology·Ulrike StampflGoetz M Richter
Jul 14, 2009·Zeitschrift für Rheumatologie·M JakobsR Guenther
Nov 13, 2008·Critical Reviews in Clinical Laboratory Sciences·Frederick D Coffman
Jan 16, 2016·Zeitschrift für Rheumatologie·K A JendrissekR Janka
Jul 14, 2010·Autoimmunity Reviews·U FioccoL Punzi
Dec 1, 2009·Journal of Vascular and Interventional Radiology : JVIR·Ulrike StampflGoetz M Richter
Jul 3, 2007·Cancer Letters·Aman GeldyyevIrina Berger
Oct 16, 2015·Scientific Reports·Abhijit MajiYogendra Singh
Aug 21, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·En-Rung ChiangShih-Chieh Hung
Apr 30, 2015·BMC Genomics·Anna L SwanJaume Bacardit
May 4, 2016·Scientific Reports·Rutika R NaikSharmila A Bapat
Aug 25, 2015·ASN Neuro·Elena SánchezCoro Paisán-Ruiz
May 25, 2016·BJR Case Reports·David McKeanJames L Teh
Feb 19, 2021·Journal of Molecular Histology·Zhenyu DingYaohua He
Jul 13, 2021·Frontiers in Immunology·Yang ZhaoXin Zhang