Analysis of plasma citrulline and intestinal morphometry in mice with hepatosplenic schistosomiasis

Surgical Infections
Luciana T SiqueiraEdmundo Machado Ferraz

Abstract

Portal hypertension in the mucosa of the intestine and the presence of granulomas in the wall of this organ can alter digestive function in patients with schistosomiasis. Citrulline is a potential marker of intestinal function in some diseases that affect the morphometry of the mucosa because of its close association with enterocytes. The aims of the present study were to determine serum citrulline concentrations in mice with hepatosplenic schistosomiasis, analyze the morphologic repercussions for the mucosa of the small intestine, correlate citrulline concentrations with morphometric changes in the intestinal mucosa, and evaluate the effect of splenectomy on citrulline concentration. After approval from the local ethics committee, 46 adult female albino Swiss mice were divided into two groups: Control (23 healthy mice) and experimental (23 mice with hepatosplenic schistosomiasis). Blood samples were collected for the analysis of plasma citrulline before and after splenectomy. A segment of the jejunum was resected for morphometric analysis. The average body mass in the control group was greater than that in the experimental group (p = 0.00062). The average citrulline concentration in the control group was greater than that in t...Continue Reading

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Citations

Feb 9, 2012·Parasitology·Alba Cristina Miranda de Barros AlencarJosé Roberto Machado-Silva
Dec 5, 2014·PLoS Neglected Tropical Diseases·Jack E T GrimesMichael R Templeton
Jun 25, 2015·Revista Da Sociedade Brasileira De Medicina Tropical·Kedma de Magalhães LimaCélia Maria Machado Barbosa de Castro
May 4, 2011·Revista do Colégio Brasileiro de Cirurgiões·Alvaro Antônio Bandeira FerrazEdmundo Machado Ferraz

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Methods Mentioned

BETA
blood
light microscopy

Software Mentioned

Image J
Statistical Package for the Social Sciences ( SPSS
Motic Images Plus

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