Analysis of platelet-reactive alloantibodies and evaluation of cross-match-compatible platelets for the management of patients with transfusion refractoriness

Transfusion Medicine
J WangS Santoso

Abstract

Cross-match-compatible platelets can improve corrected count increments (CCIs) in alloimmunised patients with transfusion refractoriness. However, only a few studies mentioned that the specificities of platelet-reactive alloantibodies can predict high reactivity in cross-match assays among these patients. A total of 204 medical records of patients who were refractory to random single-donor apheresis platelets between January 2014 and December 2014 were enrolled. Platelet-reactive antibodies in patients' serum were screened by an enzyme-linked immunosorbent assay (ELISA).The platelet cross-match assays were performed by a solid-phase adherence assay. The specificities of human leukocyte antigen (HLA) class I and human platelet antigens (HPAs) alloantibodies were determined by Luminex Single Antigen and Monoclonal Antibody-specific Immobilization of Platelet Antigens (MAIPA) assays, respectively. Anti-HLA and anti-HPA alloantibodies were found in 114 of 204 (55.88%) patients, including 110 (96.49%) with anti-HLA alloantibodies only, 2 (1.75%) with anti-HPA alloantibodies (anti-GPIIb/IIIa) only and 2 (1.75%) with both anti-HLA and anti-HPA alloantibodies (anti-HPA-3a and anti-HPA-5b). The most common HLA class I alloantibody pheno...Continue Reading

References

Jun 16, 2001·Transfusion·V KiefelS Santoso
Oct 4, 2003·American Journal of Obstetrics and Gynecology·John D Yeast, Frederick Plapp
Feb 24, 2004·Journal of the American Society of Nephrology : JASN·Martin KarpinskiPeter Nickerson
Jun 1, 2006·Transfusion·Nancy M HeddleUNKNOWN BEST Collaborative (Biomedical Excellence for Safer Transfusion)
Aug 7, 2007·Lancet·David F Stroncek, Paolo Rebulla
May 31, 2008·British Journal of Haematology·Eldad Hod, Joseph Schwartz
Mar 26, 2011·Clinics·Aline Aparecida FerreiraHelio Moraes-Souza

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Citations

Oct 5, 2018·American Journal of Clinical Pathology·Amy E SchmidtMyra Coppage
Feb 14, 2019·Einstein·Valeria de Freitas DutraJosé Mauro Kutner
Feb 25, 2021·Stem Cells and Development·Lucas Ferioli Catelli, Sara Teresinha Olalla Saad
Jun 5, 2021·Hematology, Transfusion and Cell Therapy·Natália Bollini de Araújo BarbagalloCarolina Bonet-Bub

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