Analysis of poly(ethylene glycol)-diacrylate macromer polymerization within a multicomponent semi-interpenetrating polymer network system

Journal of Biomedical Materials Research. Part a
Richard P WitteWeiyuan John Kao

Abstract

Semi-interpenetrating polymer networks (semi-IPNs) containing poly(ethylene glycol)-diacrylate (PEGdA) and modified gelatin were prepared with 2,2-dimethoxy-2-phenylacetophenone (DMPA) as a photoinitiator. The effect of (i) initiator and PEGdA concentration, and (ii) weight ratio and type of modified gelatin on the conversion of PEGdA functional end groups was monitored in situ using attenuated total reflectance-Fourier transform infrared (ATR-FTIR). Reaction induction time was dependent on DMPA concentration and increased with decreasing DMPA concentration. Relative reaction rate was strongly dependent on both DMPA and PEGdA concentrations. Gelatin weight ratio and modification did not significantly affect reaction induction time, relative reaction rate, or reaction end time. Swelling/degradation kinetics at various aqueous conditions sought to establish relationships between diacrylate conversion and the resulting semi-IPN physical properties. Semi-IPN swelling weight ratio was strongly dependent on solvent conditions and semi-IPN exposure to gamma-irradiation. Gelatin backbone modification and UV exposure time exhibited no effect on semi-IPN swelling weight ratio. In conclusion, ATR-FTIR presents a viable means of monitoring...Continue Reading

References

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Oct 1, 2003·Journal of Biomedical Materials Research. Part a·Jeanine A BurmaniaWeiyuan John Kao
Jan 6, 2004·Journal of Biomedical Materials Research. Part a·Jodi L Zilinski, Weiyuan John Kao

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Citations

Apr 27, 2012·Journal of Materials Science. Materials in Medicine·Jorge Luis Escobar IviricoManuel Monleón Pradas
May 14, 2009·Analytical Chemistry·Daniel C Pregibon, Patrick S Doyle
Mar 18, 2011·ACS Applied Materials & Interfaces·Sarbjit KaurRussell J Stewart
Jul 7, 2005·Tissue Engineering·Jeffrey M Phillips, Weiyuan John Kao
Dec 9, 2008·Journal of Burn Care & Research : Official Publication of the American Burn Association·Kyle R KleinbeckWeiyuan John Kao
Jan 10, 2009·Journal of Burn Care & Research : Official Publication of the American Burn Association·Kyle R KleinbeckWeiyuan John Kao
Jan 12, 2010·Journal of Burn Care & Research : Official Publication of the American Burn Association·Lee D FaucherWeiyuan John Kao
Apr 10, 2012·Acta Biomaterialia·Kedi XuWeiyuan John Kao
Apr 1, 2012·Advances in Wound Care·Kedi XuWeiyuan John Kao
Nov 3, 2010·Advanced Engineering Materials·Shaun D GittardRoger J Narayan
Dec 14, 2011·Macromolecular Bioscience·Benjamin F PierceAndreas Lendlein
Oct 21, 2018·Journal of the Mechanical Behavior of Biomedical Materials·Ke LuoDouglas E Spearot
Mar 23, 2021·Journal of the Mechanical Behavior of Biomedical Materials·Ke LuoDouglas E Spearot
Feb 11, 2020·The Journal of Physical Chemistry. B·Ke LuoDouglas E Spearot
Mar 9, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Pilnam Kim, Kahp Y Suh

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