PMID: 11901355Mar 20, 2002Paper

Analysis of polymorphisms in the olfactory G-protein Golf in major depression

Psychiatric Genetics
P ZillB Bondy

Abstract

It is well established that G-proteins represent essential regulatory components in transmembrane signaling. The alpha subunit of the olfactory G-protein Golf (GNAL) maps to a region on chromosome 18 where linkage to affective disorders has been reported, as well as a parent-of-origin effect in affective disorders with some markers near the locus for the alpha subunit of the Golf gene. We investigated whether two polymorphisms in the alpha subunit of the Golf gene (A-->G in intron 3, and T-->G in intron 10) are associated with major depression in 176 major depressive patients compared with 145 healthy control subjects, and additionally tested for a parent-of-origin effect in separated gender groups. In the control group, we found a significant increase in the G-allele frequency of the intron 3 polymorphism in females (P=0.0036, odds ratio=2.13, 95% confidence interval=1.29-3.54, Fisher's Exact Test). In patients, we found a similar tendency for higher G-allele frequencies in females. Concerning the intron 10 polymorphism, no differences in the genotype or allele frequencies were detectable for any of the separated gender groups. Also, the total patient and control groups showed no differences in allele or genotype frequencies f...Continue Reading

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Citations

Jul 27, 2005·Molecular Psychiatry·J P CorradiS T Furlong
Apr 11, 2007·Molecular Psychiatry·J Mill, A Petronis
Oct 17, 2007·Molecular Psychiatry·S López-LeónC M van Duijn
Sep 12, 2008·Biological Reviews of the Cambridge Philosophical Society·Bernard Crespi
Jun 14, 2008·Yi chuan = Hereditas·Yong-Hui DangZhong-Sheng Sun
Dec 15, 2006·Journal of Psychiatric Research·Nancy LaurinCathy L Barr
Dec 13, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Sofia Avissar, Gabriel Schreiber
Feb 28, 2009·Biochemical and Biophysical Research Communications·Kazumasa AkitaHideo Kaneko
Jan 6, 2006·Psychiatric Genetics·Andrew E WellerWade H Berrettini
May 23, 2009·Journal of Human Genetics·Joanne M A MeerabuxTakeo Yoshikawa

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