PMID: 8458907Mar 5, 1993Paper

Analysis of polyols in uremic serum by liquid chromatography combined with atmospheric pressure chemical ionization mass spectrometry

Journal of Chromatography
T NiwaY Kato

Abstract

Liquid chromatography with atmospheric pressure chemical ionization mass spectrometry in the negative-ion mode was used to analyse polyols in uremic serum obtained from haemodialysis patients. With post-column addition of 1% chloroform-methanol as an ionization accelerating solvent, the chloride addition ions, [M+Cl]-, were detected as base peaks, and the molecular masses of the polyols were easily determined by comparing [M+Cl]- and [M - H]- ions. Concentrations of erythritol, myoinositol, mannitol and sorbitol were markedly increased, and that of 1,5-anhydroglucitol was markedly decreased in the uremic serum compared with normal serum. After haemodialysis, the serum concentration of these polyols decreased significantly. This method was found to be useful in analysing the profile of polyols.

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Citations

Mar 29, 1996·Clinica Chimica Acta; International Journal of Clinical Chemistry·G PhillipovT H Mathew
May 18, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Songmei GaoH T Karnes
Oct 1, 1995·Clinica Chimica Acta; International Journal of Clinical Chemistry·T Niwa
Oct 1, 1995·Clinica Chimica Acta; International Journal of Clinical Chemistry·T Niwa
Dec 23, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·I C MunroW O Bernt
May 8, 2007·Analytica Chimica Acta·Eduard RogatskyDaniel T Stein
Apr 16, 2009·Diabetes Care·Vera BrilUNKNOWN Ranirestat Study Group
May 10, 2017·Proceedings of the National Academy of Sciences of the United States of America·Katie C HootmanPatricia A Cassano
Jan 13, 2018·Yeast·Frédéric Carly, Patrick Fickers
Feb 1, 2003·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Nariyasu Mano, Junichi Goto
Aug 15, 1998·Mass Spectrometry Reviews·T Niwa

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