Analysis of Predicted Host-Parasite Interactomes Reveals Commonalities and Specificities Related to Parasitic Lifestyle and Tissues Tropism

Frontiers in Immunology
Yesid Cuesta-AstrozLars J Jensen

Abstract

The study of molecular host-parasite interactions is essential to understand parasitic infection and adaptation within the host system. As well, prevention and treatment of infectious diseases require a clear understanding of the molecular crosstalk between parasites and their hosts. Yet, large-scale experimental identification of host-parasite molecular interactions remains challenging, and the use of computational predictions becomes then necessary. Here, we propose a computational integrative approach to predict host-parasite protein-protein interaction (PPI) networks resulting from the human infection by 15 different eukaryotic parasites. We used an orthology-based approach to transfer high-confidence intraspecies interactions obtained from the STRING database to the corresponding interspecies homolog protein pairs in the host-parasite system. Our approach uses either the parasites predicted secretome and membrane proteins, or only the secretome, depending on whether they are uni- or multi-cellular, respectively, to reduce the number of false predictions. Moreover, the host proteome is filtered for proteins expressed in selected cellular localizations and tissues supporting the parasite growth. We evaluated the inferred int...Continue Reading

References

May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·H J RyserG J DiSciullo
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·C G LiuG Wiche
Apr 16, 1998·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·M Aumailley, B Gayraud
Feb 26, 2000·Parasitology Today·E N Meeusen, A Balic
Jul 13, 2000·Journal of Molecular Biology·O EmanuelssonG von Heijne
May 31, 2002·Acta Crystallographica. Section D, Biological Crystallography·Helen M BermanChristine Zardecki
Apr 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Debra S Goldberg, Frederick P Roth
May 13, 2003·Nature Biotechnology·Alexei VazquezAlessandro Vespignani
Jan 24, 2007·Parasite Immunology·D P Knox
Jul 24, 2007·Molecular and Biochemical Parasitology·Cynthia L CassDavid L Williams
Jul 25, 2007·Bioinformatics·Matthew D DyerBruno W Sobral
Oct 30, 2007·Protein Science : a Publication of the Protein Society·Fred P DavisAndrej Sali
Oct 10, 2008·BMC Genomics·Sailu YellaboinaMinoru Sh Ko
Oct 22, 2008·Malaria Journal·Marissa VignaliStanley Fields
Feb 17, 2009·Cell Host & Microbe·Kellen L OlszewskiManuel Llinás
Apr 25, 2009·Cellular Microbiology·Thomas Areschoug, Siamon Gordon
Sep 12, 2009·Bioinformatics·David BinnsRolf Apweiler
Feb 16, 2010·Current Opinion in Immunology·Romina S Goldszmid, Alan Sher
Nov 12, 2010·Nucleic Acids Research·David CroftLincoln Stein
Nov 13, 2010·Nucleic Acids Research·Chris StarkMike Tyers
Feb 24, 2011·Infection and Immunity·Patricio A ManqueGregory A Buck
May 11, 2011·PloS One·Christina M TaylorMakedonka Mitreva
May 20, 2011·Nucleic Acids Research·Robert D FinnSean R Eddy
Oct 1, 2011·Clinical and Vaccine Immunology : CVI·Christof StraubMartín Montes
Oct 1, 2011·Nature Methods·Thomas Nordahl PetersenHenrik Nielsen
Nov 11, 2011·BMC Bioinformatics·John H MorrisThomas E Ferrin
Nov 30, 2011·The Journal of Cell Biology·Joe Grove, Mark Marsh
Dec 6, 2011·Pharmacology & Therapeutics·Nathalie GeurtsPhilippe E Van den Steen

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Citations

Nov 30, 2019·International Journal of Molecular Sciences·Tawanda Zininga, Addmore Shonhai
Dec 29, 2019·BMC Genomics·Tungadri BoseSharmila S Mande
Sep 23, 2020·Molecular Biology and Evolution·Yibo HuFuwen Wei
Nov 17, 2020·Frontiers in Cellular and Infection Microbiology·Xin-Zhuan SuDeirdre A Joy
May 29, 2021·Frontiers in Microbiology·Padhmanand SudhakarSéverine Vermeire
Aug 7, 2021·Vaccines·Ndibonani Kebonang QokoyiAbidemi Paul Kappo

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Methods Mentioned

BETA
interaction
interaction predictions
protein folding

Software Mentioned

3did
OrthoHPI
iPfam
TargetP
Graph Modeling
HMMER
Cytoscape
clusterMaker app
SignalP
STRING

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