PMID: 9169815Mar 15, 1997Paper

Analysis of prognostic factors in stage IIB-IVA cervical carcinoma treated with radiation therapy: value of computed tomography

International Journal of Radiation Oncology, Biology, Physics
I OginoS Matsubara

Abstract

To define the influence of the tumor size measured by computed tomography (CT) and lymph node involvement detected by CT in patients treated with radiation therapy for Stage IIB-IVA carcinoma of intact uterine cervix. This was a retrospective analysis of 233 patients with uterine cervical cancer managed with both external irradiation and high-dose-rate intracavitary brachytherapy (HDR-ICR) at Kanagawa Cancer Center. The results were analyzed for the end points of absolute survival (AS), disease-free survival (DFS), pelvic control (PC), and central control (CC). The parameters of stage, CT-measured anterior-posterior (AP) cervix size, and CT-detected lymph node metastases were evaluated using univariate and multivariate analysis. The stage, AP cervix size, and lymph node involvement were significant pretreatment factors in univariate analysis with respect to AS, DFS, PC, and CC. Multivariate analysis confirmed that significant risk was associated with certain prognostic parameters. Those in terms of AS, in order of decreasing significance, were lymph node involvement, AP cervix size, age, and total HDR-ICR dose. When DFS was studied, lymph node involvement and AP cervix size were demonstrated to have a significant effect. Stage ...Continue Reading

References

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Citations

Jul 30, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ichiro OginoHiroki Nakayama
Jul 15, 2005·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·I OginoT Inoue
Jun 29, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·I OginoT Inoue
Sep 13, 2001·Radiographics : a Review Publication of the Radiological Society of North America, Inc·H K PannuE K Fishman
Nov 7, 2003·Cancer·Harpreet K Pannu, Elliot K Fishman
Mar 5, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Patricia J EifelSusan Tucker
Jun 6, 2018·The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica·Judit A AdamBerthe L van Eck-Smit
Oct 2, 2014·Australian and New Zealand Journal of Public Health·David A GibsonD'Arcy J Holman
Jan 25, 2003·Current Opinion in Obstetrics & Gynecology·Michael Zimny, Wulf Siggelkow

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