Analysis of prognostic factors of chemoradiation therapy for advanced hypopharyngeal cancer--does tumor volume correlate with central necrosis and tumor pathology?

ORL; Journal for Oto-rhino-laryngology and Its Related Specialties
Yung An TsouMing-Hsui Tsai

Abstract

Not all patients with hypopharyngeal cancer who undergo concurrent chemoradiation therapy have a good prognosis. We hope to find the significant prognostic factors that could help us in patient selection for concurrent chemoradiation therapy. We used a retrospective analysis on several prognostic factors which may affect the treatment outcome and prognosis. We studied 51 patients with stage III-IV hypopharyngeal cancer who underwent chemoradiation therapy as the first treatment method. Possible significant prognostic factors (i.e. tumor volume, central necrosis, pathology, age) were collected to determine whether they correlate with local disease control and survival. Primary tumor volume correlated with local disease control and survival. The greatest risk for local failure was found among patients with primary tumor volumes >19.0 ml (p = 0.001). Other relatively significant prognostic factors were pathology and central necrosis. The survival rate among patients with primary tumor volumes >19.0 ml was only 39.3% compared with 78.3% for patients with volumes <19.0 ml (p = 0.036). A proportional hazard model indicated that significant parameters associated with overall survival were primary tumor volume (p = 0.036) and central n...Continue Reading

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Citations

Oct 31, 2007·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Yung-An TsouMing-Hsui Tsai
Sep 5, 2013·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·G Studer, C Glanzmann
Jun 20, 2012·Auris, Nasus, Larynx·Jimmy Yu Wai Chan, William Ignace Wei
Mar 20, 2010·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Tang Chuan WangMing Hsui Tsai
Jan 10, 2012·Head & Neck·Robert P TakesUNKNOWN International Head and Neck Scientific Group
Mar 5, 2014·Journal of Surgical Oncology·Chan-Joo YangSang Yoon Kim
Jan 16, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Geert O JanssensJohannes H Kaanders
Aug 5, 2016·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Parveen AhlawatShraddha Jain
May 3, 2020·World Journal of Surgical Oncology·Yao-Te TsaiKai-Ping Chang
Jul 29, 2020·Journal of Cancer Research and Therapeutics·Janaki Gururajachar Manur, Nishant Vidyasagar
Dec 17, 2016·Molecular Cancer Therapeutics·Sanne R Martens-de KempRuud H Brakenhoff

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