Analysis of proliferation markers and p53 expression in gliomas of astrocytic origin: relationships and prognostic value

Journal of Neurosurgery
J M CunninghamR B Jenkins

Abstract

Consecutive paraffin sections of 105 astrocytomas and 15 oligoastrocytomas were examined for expression of p53, MIB-1 (Ki-67), and proliferating cell nuclear antigen (PCNA). The tumors had been examined previously for genetic abnormalities and by flow cytometry. Regardless of the tumor's stage and grade and the patient's age and gender, p53 expression was found in 40% of tumors. Although p53 expression was associated with a loss on chromosome 17p and was more frequent in aneuploid tumors, it had no association with survival time. The MIB-1 and PCNA labeling indices increased with increasing tumor grade but showed no association with other clinicopathological parameters. In individual tumors, there was poor concordance between any of the variables (MIB-1, PCNA, and p53). Results for p53 and MIB-1 were similar for both astrocytomas and oligoastrocytomas. The MIB-1 and PCNA values appeared to have prognostic utility in univariate analysis but not after adjusting for patient age and tumor grade. The poor concordance between MIB-1 and PCNA in individual tumors indicates that any one means of assessing proliferative potential in gliomas may not be reliable.

References

Sep 1, 1992·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·H K Wolf, K L Dittrich
Jul 1, 1992·Journal of Clinical Pathology·M BarbareschiC Doglioni
Jan 1, 1991·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M D Coltrera, A M Gown
Aug 1, 1991·Journal of Clinical Pathology·S JainD A Levison
Sep 1, 1991·Genes, Chromosomes & Cancer·R ChungR Martuza
Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·W E MercerS J Ullrich
Jan 1, 1991·Virchows Archiv. A, Pathological Anatomy and Histopathology·A AllegranzaM Barbareschi
Jun 1, 1987·Mayo Clinic Proceedings·C Daumas-DuportP J Kelly
Nov 15, 1988·Cancer·C Daumas-DuportP Kelly
Dec 1, 1988·Journal of Neurosurgery·T HoshinoR L Davis
May 1, 1987·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·J J Kepes
Sep 1, 1982·Annals of Neurology·W R Shapiro
Oct 1, 1994·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Y SoiniK Vähäkangas
Nov 1, 1994·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·L C AngD Shul
Apr 1, 1993·The Journal of Pathology·E SabattiniB Falini
Apr 1, 1993·Neuropathology and Applied Neurobiology·T ReveszD G Thomas
Mar 1, 1994·British Journal of Cancer·P IuzzolinoM Barbareschi
Nov 1, 1993·Journal of Neuropathology and Experimental Neurology·S W Coons, P C Johnson
Nov 19, 1993·Cell·W S el-DeiryB Vogelstein
Dec 16, 1993·Nature·Y XiongD Beach

❮ Previous
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Citations

Aug 14, 2002·Cancer·Ahmed RasheedRoger E McLendon
Jan 1, 1997·Acta neurochirurgica·W T CouldwellC B Stillerman
Feb 15, 2012·Brain Tumor Pathology·Yoshiko OkitaSoichiro Shibui
Oct 20, 2005·Journal of Neuro-oncology·Shaye I MoskowitzRichard A Prayson
Dec 23, 2008·Journal of Neuro-oncology·Masayuki KanamoriTeiji Tominaga
May 2, 2012·Pathology Oncology Research : POR·A KulkarniB A Chandramouli
Dec 4, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M CapraE Bouffet
Sep 25, 2001·International Journal of Radiation Oncology, Biology, Physics·F G BarkerK D Aldape
Mar 3, 1998·Journal of the American College of Surgeons·I A Awad
Feb 8, 2002·The New England Journal of Medicine·Ian F PollackUNKNOWN Children's Cancer Group
Aug 16, 2001·Journal of the National Cancer Institute·J S SmithR B Jenkins
May 20, 1998·Pathology International·Y Takekawa, T Sawada
Mar 1, 2005·Journal of Clinical Pathology·J HaapasaloJ Isola
May 16, 1998·The Journal of Clinical Investigation·J A LevineT O'Brien
Nov 12, 2003·Journal of Neurosurgery·Kuo-Sheng Hung, Shen-Long Howng
Apr 18, 2002·International Journal of Radiation Oncology, Biology, Physics·Barbara J FisherLarry Stitt
Feb 8, 2000·Cancer Treatment Reviews·C NiederH D Thames
Jan 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jan C BucknerRobert Jenkins
Jul 6, 2004·Arquivos de neuro-psiquiatria·Marlise de Castro RibeiroArlete Hilbig
Mar 21, 2002·Histopathology·D C Brown, K C Gatter
Feb 19, 2002·Neuropathology and Applied Neurobiology·P KorkolopoulouP Davaris
May 1, 2001·Pathology International·H HoriguchiT Hirose
Oct 3, 1999·Pathology International·H HoriguchiS Nagahiro
Apr 24, 2004·Neurosurgical Focus·N S Litofsky, L D Recht
Dec 22, 1999·British Journal of Cancer·S BalesariaR A Fisher
Sep 15, 2001·Applied Immunohistochemistry & Molecular Morphology : AIMM·P KorkolopoulouP Davaris
May 20, 1998·The American Journal of Surgical Pathology·B Quinn

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