Analysis of PSMA expression and outcome in patients with advanced Prostate Cancer receiving 177Lu-PSMA-617 Radioligand Therapy.

Theranostics
Robert SeifertKambiz Rahbar

Abstract

Rationale: PSMA-PET-CT enables measuring molecular expression of prostate-specific membrane antigen (PSMA) in vivo, which is the target molecule of 177Lu-PSMA-617 (Lu-PSMA) therapy. However, the correlation of PSMA expression and overall survival (OS) in patients treated with Lu-PSMA therapy is currently unclear; especially with regard to coexistence of high and low PSMA expressing metastases. To this end, this retrospective single arm study elucidates the correlation of PSMA expression and overall survival in patients treated with Lu-PSMA therapy. Additionally, PET based criteria to define low PSMA expression were explored. Methods: Eighty-five patients referred to Lu-PSMA therapy were included in the analysis. Pretherapeutic 68Ga-PSMA-PET-CT scans were available for all patients. SUVmax of the highest PSMA expressing metastasis (PSMAmax), SUVmax of the lowest PSMA expressing metastasis (PSMAmin), and average SUVmax of all metastases (PSMAaverage) amongst other PET parameters were measured for each patient. A log-rank cutoff-finder was used to determine low (lowPSMAaverage) and high (highPSMAaverage) average PSMA expression as well as low (lowPSMAmin) and high (highPSMAmin) minimal PSMA expression. Results: PSMAaverage was a s...Continue Reading

Citations

Jan 30, 2021·Seminars in Nuclear Medicine·Robert SeifertDavid Kersting
Dec 3, 2020·International Journal of Molecular Sciences·Finn Edler von EybenGiovanni Paganelli
Mar 9, 2021·Frontiers in Oncology·Panagiotis J VlachostergiosScott T Tagawa
Mar 30, 2021·Current Oncology Reports·Michael SunScott T Tagawa
Jun 1, 2021·PET Clinics·Ian L AlbertsAli Afshar-Oromieh
Jun 1, 2021·PET Clinics·Robert SeifertKambiz Rahbar
Jan 15, 2021·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Nahid YusufiMatthias Eiber
Jun 30, 2021·Current Opinion in Oncology·Carlos ArtigasIoannis Karfis
Aug 28, 2021·Research and Reports in Urology·Rita ViglialoroPaola Anna Erba
Aug 7, 2021·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Amir Iravani, Thomas A Hope
Nov 3, 2021·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jeremie Calais, Johannes Czernin

❮ Previous
Next ❯

Software Mentioned

MI Whole Body Analysis Suite ( MIWBAS
SPSS
maxstat
R

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Kyle CurrentKatharina Lueckerath
The Prostate
G P MurphyG M Kenny
APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
Alla Gabriella WernickeSandra J Shin
© 2021 Meta ULC. All rights reserved